PMID: 8583973May 1, 1995Paper

Pre-eclampsia: excessive activation of a G protein-associated receptor?

Medical Hypotheses
C G Coffey

Abstract

Although the systemic physiological alterations present in pre-eclampsia appear disparate and unrelated, four of them (endothelial cell hyperplasia and alterations in uric acid, calcium, and prostaglandin homeostasis) are demonstrated here to mimic closely the pattern of intracellular alterations caused by the activation of a G protein-associated receptor. The implication of this is that the excessive activation of a particular G protein-associated receptor may play a central role in the pathogenesis of pre-eclampsia.

References

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Citations

Apr 25, 2003·Medical Hypotheses·Charles G Coffey

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