Pre-emptive epidural ketamine or S(+)-ketamine in post-incisional pain in dogs: a comparative study

Veterinary Surgery : VS
Juan Carlos Duque MNilson Oleskovicz

Abstract

To compare the pre-emptive analgesic effects of epidural ketamine or S(+)-ketamine on post-incisional hyperalgesia. Prospective randomized study. Twenty-four mongrel dogs (1-5 years, weighing 11.9+/-1.8 kg). Dogs were anesthetized with propofol (5 mg/kg intravenously) and a lumbosacral epidural catheter was placed. Dogs were randomly allocated to 3 groups, each with 8 dogs. The control group (CG) was administered saline solution (0.3 mL/kg); the ketamine group (KG) ketamine (0.6 mg/kg); and the S(+)-ketamine group (SG) S(+)-ketamine (0.6 mg/kg). The final volume was adjusted to 0.3 mL/kg in all groups. Five minutes after the epidural injection a surgical incision was made in the common pad of the right hind limb and was immediately closed with simple interrupted nylon suture. Respiratory (RR) and heart (HR) rates, rectal temperature (T), sedation (S), lameness score, and mechanical nociceptive threshold by von Frey filaments were evaluated before the propofol anesthesia and at 15, 30, 45, 60, 75, and 90 minutes and then at 2, 4, 6, 8, 12, and 24 hours after epidural injection. There were no differences in RR, HR, T, or S between groups. Motor blockade of the hind limbs was observed during 20+/-3.6 minutes in KG and during 30.6+...Continue Reading

References

Sep 1, 1991·British Journal of Anaesthesia·J L PedrazA Dominguez-Gil
Jul 31, 1986·European Journal of Pharmacology·P Arhem, B Rydqvist
Mar 1, 1994·British Journal of Anaesthesia·T A CrozierD Kettler
Dec 1, 1993·Anesthesia and Analgesia·L RoytblatA Fisher
Apr 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S AlamY Kosaka
Dec 5, 1997·Veterinary Surgery : VS·D D MartinG J Benson
Mar 12, 1998·Anesthesia and Analgesia·C T HartrickJ S Patterson
Jul 15, 1998·Veterinary Surgery : VS·I A Gómez de SeguraF San-Roman
May 4, 2000·British Journal of Anaesthesia·P MarhoferM Semsroth
Oct 1, 2002·Veterinary Anaesthesia and Analgesia·Márcia A RéduaLúcia T Balestrero

❮ Previous
Next ❯

Citations

Feb 24, 2009·Journal of Feline Medicine and Surgery·Juliana Tabarelli BrondaniCarlos Roberto Padovani
Feb 4, 2006·American Journal of Veterinary Research·Alonso G P GuedesElaine P Rudé
Sep 10, 2010·European Journal of Pharmacology·Eric Schmidt RondonCarlos Amilcar Parada
Oct 29, 2008·The Veterinary Clinics of North America. Small Animal Practice·Leigh A Lamont
Oct 29, 2008·The Veterinary Clinics of North America. Small Animal Practice·Alexander Valverde
May 13, 2006·Reproduction in Domestic Animals = Zuchthygiene·A Ortega-PachecoC Linde Forsberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.