Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
Gideon Koren, Caroline Maltepe

Abstract

Nausea and vomiting of pregnancy (NVP) affects 80% of pregnancies. Its severe form, hyperemesis gravidarum (HG), results in dehydration, electrolyte imbalance, the need for hospitalisation and can, rarely, be fatal. This was a prospective, open-labelled, controlled, interventional study to evaluate the effectiveness of pre-emptive treatment of NVP symptoms in women who experienced severe NVP or HG in their previous pregnancy. Twenty-five women who reported severe symptoms of NVP with or without HG in their previous pregnancy were recruited and counselled to commence the use of antiemetics as soon as they became aware of the present pregnancy, and no later than the beginning of symptoms. They were followed-up prospectively through the index pregnancy for symptoms of NVP, and were counselled continuously as to how to modify antiemetic doses based on symptoms. A comparison group consisted of randomly selected women also counselled by us for NVP, who had also had severe NVP in the previous pregnancy, but who did not call before a planned pregnancy and thus could not be offered pre-emptive therapy. The recruited women commenced pre-emptive drug therapy for NVP before conception or up to 7 weeks' gestation, before the appearance of N...Continue Reading

References

Sep 1, 1968·American Journal of Obstetrics and Gynecology·D V Fairweather
Aug 24, 1999·Reproductive Toxicology·P MazzottaG Koren
May 16, 2002·American Journal of Obstetrics and Gynecology·Thomas Murphy Goodwin

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Citations

Mar 23, 2011·Archives of Gynecology and Obstetrics·Shipra Sonkusare
Oct 3, 2003·Health and Quality of Life Outcomes·Andrew Symon
Nov 17, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A G Tamay, N K Kuşçu
Mar 6, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·Cecilia Bottomley, Tom Bourne
Sep 2, 2008·Obstetrics and Gynecology Clinics of North America·T Murphy Goodwin
Dec 12, 2007·Psychosomatics·Mark T Wright
Sep 25, 2007·Best Practice & Research. Clinical Gastroenterology·Siti Khadijah Ismail, Louise Kenny
May 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lorene TemmingSaju Joy
Aug 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Hsiao-Ling WangLih-Mih Chen
Mar 12, 2013·Obstetrics and Gynecology International·Caroline Maltepe, Gideon Koren
Sep 9, 2015·The Cochrane Database of Systematic Reviews·Anne MatthewsTherese Dowswell
Dec 7, 2018·BMJ : British Medical Journal·Caitlin R DeanRebecca C Painter
Mar 3, 2011·Expert Opinion on Pharmacotherapy·Olaleye Sanu, Ronald F Lamont
Sep 14, 2019·Nature Reviews. Disease Primers·Marlena S FejzoPatrick M Mullin
Dec 6, 2018·Journal of Pregnancy·Relin van VlietRebecca C Painter
May 26, 2021·Acta Obstetricia Et Gynecologica Scandinavica·Kelly NijstenRebecca C Painter

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