Pre-evacuation hCG glycoforms in uneventful complete hydatidiform mole and persistent trophoblastic disease

Gynecologic Oncology
C M G ThomasF C G J Sweep

Abstract

To investigate whether the glycoform distribution patterns of human chorionic gonadotropin (hCG) obtained by chromatofocusing in pre-evacuation serum are different for patients who will eventually develop into persistent trophoblastic disease in case of complete hydatidiform mole pregnancy as compared to those patients for whom trophoblastic tissue will regress uneventfully. Pre-evacuation blood samples were collected from women with complete hydatidiform mole with uneventful spontaneous regression after molar evacuation (n=32), from women with complete hydatidiform mole who developed persistent trophoblastic disease after evacuation of their mole (n=28) and, as a control group, from women during the first trimester of normal pregnancy (n=22). The serum specimens were subjected to chromatofocusing, and hCG was determined in the fractions collected in the pH range 7.0-3.0. Receiver operating characteristics (ROC) analysis revealed that 36% of complete hydatidiform mole patients with post-molar persistent trophoblastic disease development had different hCG glycoform profiles at 97% specificity (pH interval 6.3-5.1, hCG cutoff 9.9%). There was a significant difference between complete hydatidiform mole with and without persistent ...Continue Reading

References

Mar 1, 1990·Gynecologic Oncology·L W RiceM R Bernstein
Jun 1, 1987·The Journal of Clinical Endocrinology and Metabolism·L A ColeA Decherney
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May 16, 2003·American Journal of Obstetrics and Gynecology·Sarah A KhanlianLaurence A Cole
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nienke E van TrommelChris M Thomas

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Citations

Oct 24, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Parichehr KimiaeeZaynab Bakhtiyari
May 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Charlotte LybolChris M G Thomas

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