Pre-Interventional Kynurenine Predicts Medium-Term Outcome after Contrast Media Exposure Due to Coronary Angiography

Kidney & Blood Pressure Research
Christoph ReichetzederBerthold Hocher

Abstract

Contrast induced acute kidney injury (CI-AKI) remains a serious complication of contrast media enhanced procedures like coronary angiography. There is still a lack of established biomarkers that help to identify patients at high risk for short and long-term complications. The aim of the current study was to evaluate plasma kynurenine as a predictive biomarker for CI-AKI and long-term complications, measured by the combined endpoint "major adverse kidney events" (MAKE) up to 120 days after CM application. In this prospective cohort study 245 patients undergoing coronary angiography were analyzed. Blood samples were obtained at baseline, 24h and 48h after contrast media (CM) application to diagnose CI-AKI. Patients were followed for 120 days for adverse clinical events including death, the need for dialysis, and a doubling of plasma creatinine. Occurrence of any of these events was summarized in the combined endpoint MAKE. Preinterventional plasma kynurenine was not associated with CI-AKI. Patients who later developed MAKE displayed significantly increased preinterventional plasma kynurenine levels (p<0.0001). ROC analysis revealed that preinterventional kynurenine is highly predictive for MAKE (AUC=0.838; p<0.0001). The optimal ...Continue Reading

Citations

Feb 15, 2019·Nature Reviews. Drug Discovery·Michael PlattenChristiane A Opitz
Oct 17, 2017·Oncotarget·Christoph Reichetzeder, Berthold Hocher
Dec 11, 2019·British Journal of Cancer·Christiane A OpitzSaskia Trump
Oct 8, 2021·Pharmacological Reports : PR·Izabela Zakrocka, Wojciech Załuska
Apr 3, 2019·Kidney & Blood Pressure Research·Chang ChuBerthold Hocher

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