PMID: 8944330Jan 1, 1996Paper

Pre-morbid body-mass-index in breast cancer: reversed effect on survival in hormone receptor negative patients

Breast Cancer Research and Treatment
B O Maehle, S Tretli

Abstract

The present study consists of 1,238 women with unilateral breast cancer treated with modified radical mastectomy living in the geographic area of Haukeland Hospital. Their weight and height had been measured years before presentation of the disease. Age-adjusted Quetelet's index (weight/height2) showed that obese women had a 49% higher risk of dying from breast cancer than lean ones. The relative risk decreased slightly when adjusted for tumour diameter, lymph node status, and mean nuclear area of the tumour cells. The prognostic effect of Quetelet's index was examined according to the estrogen and/or progesterone receptor status of the tumour. In patients with a hormone receptor positive tumour, obese women had a risk that was more than three times higher than lean ones. In patients with hormone receptor negative tumour, the effect of obesity was reversed, lean patients having a risk that was more than six times higher than obese ones, even after adjustment for lymph node status, tumour diameter, and mean nuclear area. Quetelet's index, while being a prognostic variable in its own right, thus acts differently in patients with hormone receptor positive and negative tumours.

References

Dec 1, 1976·The Tohoku Journal of Experimental Medicine·R AbeT Nakamura
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D GiuffridaA Belfiore
Jan 1, 1992·Annals of Internal Medicine·R T SenieD W Kinne
Oct 1, 1990·Breast Cancer Research and Treatment·P J Goodwin, N F Boyd
Aug 1, 1990·British Journal of Cancer·S TretliL Ottestad
Jul 15, 1989·International Journal of Cancer. Journal International Du Cancer·S Tretli
Feb 1, 1989·American Journal of Epidemiology·R VerreaultF Naud
Sep 15, 1988·International Journal of Cancer. Journal International Du Cancer·J R HebertE L Wynder
May 1, 1986·American Journal of Epidemiology·S C NewmanG R Howe
Jan 1, 1985·The Journal of Clinical Endocrinology and Metabolism·W H ClelandE R Simpson
Jan 1, 1985·Breast Cancer Research and Treatment·T EberleinM E Lippman
May 1, 1985·British Journal of Cancer·E R GreenbergD Yeates
May 1, 1981·Cancer·P I TartterA H Aufses
Jul 18, 1980·JAMA : the Journal of the American Medical Association·A SohrabiH C Polk

❮ Previous
Next ❯

Citations

Dec 7, 2005·Breast Cancer Research and Treatment·James J DignamD Lawrence Wickerham
Oct 17, 2007·Breast Cancer Research and Treatment·Bilal MajedBernard Asselain
Jul 15, 2009·Breast Cancer Research and Treatment·Carole DegliseHelena Marieke Verkooijen
Jan 9, 2010·Breast Cancer Research and Treatment·Xiaoli ChenXiao Ou Shu
May 9, 2012·Breast Cancer Research and Treatment·Saroj NiraulaPamela J Goodwin
Mar 17, 2004·The Breast : Official Journal of the European Society of Mastology·A R Carmichael, T Bates
Jan 9, 2001·Journal of Clinical Epidemiology·C N KlabundeJ L Warren
Feb 24, 2001·Breast Cancer Research and Treatment·S ChangA U Buzdar
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Apr 19, 2012·BMC Cancer·Masaaki KawaiYoichiro Kakugawa
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cheryl L Rock, Wendy Demark-Wahnefried
May 1, 2012·Annual Review of Nutrition·Niyati ParekhElisa V Bandera
Apr 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S M ChanT Norat
Sep 30, 2014·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Robert W O'Rourke
Jul 1, 2006·Women's Health·Deborah J Clegg, Sue C Heffelfinger
Oct 9, 2012·Clinical Breast Cancer·Shaheenah DawoodAna M Gonzalez-Angulo
Oct 30, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Bjørn Ove MaehleThor Thorsen
Aug 20, 2008·International Journal of Cancer. Journal International Du Cancer·Luigino Dal MasoUNKNOWN Prospective Analysis of Case-control studies on Environmental factors and health (PACE) study group
Dec 10, 2003·Seminars in Oncology·Wendy Demark-Wahnefried, Cheryl L Rock
Jul 23, 2016·Annals of Surgical Oncology·Laura E G WarrenJennifer R Bellon
Jun 19, 2013·The Journal of Surgical Research·Ronny MowadRoger H Kim
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Jul 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gillian C BarnettPaul D P Pharoah
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Diana S M BuistRebecca A Silliman
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rowan T ChlebowskiAnne McTiernan
Jul 13, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D P RoseG D Stephenson
Aug 24, 2004·Oncogene·Eugenia E Calle, Michael J Thun
Jan 28, 2003·Cancer·Judith Clancy Keen, Nancy E Davidson
Dec 30, 2004·Nutrition and Cancer·Margot P ClearyNita J Maihle
Dec 13, 2005·American Journal of Epidemiology·Meng-Hua TaoWei Zheng
May 8, 2003·The Journal of Biological Chemistry·Stefania CatalanoSebastiano Andò
Feb 27, 2004·The Journal of Biological Chemistry·Stefania CatalanoSebastiano Andó
Mar 10, 2011·Cancer·Foluso O AdemuyiwaStephen B Edge
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P J GoodwinS Redwood

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.