Pre-operative fluid bolus for improved haemodynamic stability during minor surgery: A prospectively randomized clinical trial

Acta Anaesthesiologica Scandinavica
T KratzH Aust

Abstract

Haemodynamic instability during the induction of anaesthesia and surgery is common and may be related to hypovolaemia caused by pre-operative fasting or chronic diuretic therapy. The aim of our prospective, controlled, randomized study was to test the hypothesis that a predefined fluid bolus given prior to general anaesthesia for minor surgery would increase haemodynamic stability during anaesthetic induction. Two hundred and nineteen fairly healthy adult patients requiring minor surgery were enrolled. All received standard treatment, including a pulse contour analysing device for non-invasive measurement of cardiac index. Infusion therapy was started in all patients at induction. The intervention group (106 patients) was randomized to receive an additional fluid bolus of 8 mL/kg Ringer's acetate solution before the induction of anaesthesia. The primary endpoint was the incidence of haemodynamic instability, defined as a significant reduction of blood pressure or cardiac index during induction of anaesthesia. The interventional group had a lesser incidence of haemodynamic instability during induction (41.5% vs 56.6%, P = .025). This group also had higher cardiac index, stroke volume index, systolic and mean blood pressure and a...Continue Reading

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Citations

Jan 17, 2019·Acta Anaesthesiologica Scandinavica·Konstantin YastrebovEvgeniy Polovnikov
Jun 27, 2019·Acta Anaesthesiologica Scandinavica·Tomi MyrbergMagnus Hultin
Oct 8, 2020·Current Opinion in Anaesthesiology·Sabine FriedrichPeter Kranke

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