Pre-operative histological diagnosis of breast cancer

The Australian and New Zealand Journal of Surgery
J W Serpell, W R Johnson

Abstract

A concordant triple assessment (clinical, mammographic and cytological) diagnosis of breast malignancy allows for pre-operative planning of surgery and may also allow for one-stage surgery. However, while the accuracy of cytology is high, it is unable to distinguish invasive cancer from ductal carcinoma in situ (DCIS). A malignant mass may be due to pure in situ cancer and hence axillary dissection may be avoided if pre-operative histology is available. A consecutive series of 300 cases of breast cancer treated over the last 5 years by the two authors was analysed to determine: the method of achieving pre-definitive operation histology; the number of stages of surgery required; and the number of cases of mass-forming DCIS which could be susceptible to over-treatment. Of 289 patients undergoing local definitive surgery for breast cancer, 12 (42%) had clinical masses predominantly due to DCIS and in most of these patients axillary dissection was avoided. Histology was obtained prior to definitive surgery in 272 (94.1%) patients, by intra-operative frozen section in 159 (55.0%), incisional biopsy in 37 (12.8%), needle localization biopsy in 62 (21.5%) and core biopsy in 14 (4.8%). A total of 189 patients (65.4%) underwent one-stag...Continue Reading

References

Jan 1, 1990·Breast Cancer Research and Treatment·B H MasonR G Kay
Jul 18, 1994·The Medical Journal of Australia·D J HillP R Kitchen
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J Greenall
Aug 1, 1993·The Australian and New Zealand Journal of Surgery·M J ByrneF G Cameron
Jan 1, 1995·Clinical Oncology : a Journal of the Royal College of Radiologists·E J Maher
Jul 1, 1997·The Australian and New Zealand Journal of Surgery·I LindseyA Rodger
Dec 30, 1994·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M NoguchiI Miyazaki
Nov 1, 1992·The Australian and New Zealand Journal of Surgery·F T McDermott

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Citations

Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ph MeijnenE J Th Rutgers
Jun 8, 2000·The Australian and New Zealand Journal of Surgery·P R KitchenM A Henderson
Jun 13, 2003·ANZ Journal of Surgery·Michael S P ChengStewart A Hart

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