Pre-Operative Perfusion Skewness and Kurtosis Are Potential Predictors of Progression-Free Survival after Partial Resection of Newly Diagnosed Glioblastoma

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Wooyul PaikSang Joon Kim

Abstract

To determine whether pre-operative perfusion skewness and kurtosis derived from normalized cerebral blood volume (nCBV) histograms are associated with progression-free survival (PFS) of patients after partial resection of newly diagnosed glioblastoma. A total of 135 glioblastoma patients who had undergone partial resection of tumor (resection of < 50% of pre-operative tumor volume or surgical biopsy) confirmed with immediate postsurgical MRI and examined with both conventional MRI and dynamic susceptibility contrast (DSC) perfusion MRI before the surgery were retrospectively reviewed in this study. They had been followed up post-surgical chemoradiotherapy for tumor progression. Using histogram analyses of nCBV derived from pre-operative DSC perfusion MRI, patients were sub-classified into the following four groups: positive skewness and leptokurtosis (group 1); positive skewness and platykurtosis (group 2); negative skewness and leptokurtosis (group 3); negative skewness and platykurtosis (group 4). Kaplan-Meier analysis and multivariable Cox proportional hazards regression analysis were performed to determine whether clinical and imaging covariates were associated with PFS or overall survival (OS) of these patients. According ...Continue Reading

References

May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B R RosenT J Brady
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L OstergaardB R Rosen
Mar 7, 2000·Frontiers in Bioscience : a Journal and Virtual Library·J S Smith, R B Jenkins
Nov 22, 2005·International Journal of Radiation Oncology, Biology, Physics·Yue CaoTheodore S Lawrence
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Sep 24, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Geon-Ho JahngFernando Calamante

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Citations

Jul 4, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Bumwoo ParkJeong Kon Kim
May 4, 2018·Journal of Neuro-oncology·Andrea RomanoAlessandro Bozzao

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Methods Mentioned

BETA
biopsy
ICE

Software Mentioned

Matlab
Nordic ICE
SPSS

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