Pre-ovulatory granulosa cells of infertile women with endometriosis are less sensitive to luteinizing hormone

American Journal of Reproductive Immunology : AJRI
D J CahillPeter G Wardle

Abstract

Reduced fertilization rates in women with minor endometriosis may be the result of direct effects on the ovary or to primary dysfunction within the hypothalamic-pituitary-ovarian axis. This controlled study was designed to examine the steroidogenic potential of luteinized granulosa cells in women with minor endometriosis. Granulosa cells were harvested at oocyte recovery and incubated for 3 hr in increasing concentrations of luteinizing hormone (LH). The dissociation constant for added concentrations of LH was computed (as Km LH) and the results were compared between women with endometriosis and controls. Women with minor endometriosis had a higher dissociation constant than women with tubal damage [Km 0.98 (0.58-9.24) versus 0.33 (0.28-0.72) ng/mL, P = 0.019], indicating reduced sensitivity to LH. In women with endometriosis, granulosa cells were less sensitive to LH stimulation. This provides further evidence for primary ovarian dysfunction as a significant contributory cause of the associated subfertility.

References

Feb 1, 1991·Molecular and Cellular Endocrinology·S G HillierA J Mason
Mar 1, 1995·Human Reproduction·U M FahyM G Hull
Aug 1, 1995·Human Reproduction·J GrimwoodM C Rees
Feb 3, 1998·Journal of Assisted Reproduction and Genetics·D J CahillM G Hull

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Citations

May 1, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Fernanda A MafraCaio P Barbosa
Sep 27, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Ana Maria SanchezPaola Vigano
Aug 9, 2005·Fertility and Sterility·Atsushi YanaiharaTakumi Yanaihara
Oct 3, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lauriane Giselle de AbreuMarcos Dias De Moura
Jul 11, 2006·Annual Review of Genomics and Human Genetics·Arman A BashirovaMary Carrington
Apr 15, 2021·Reproductive Medicine and Biology·Ya-Ching Chou, Chii-Ruey Tzeng

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