Pre-pregnancy, obstetric and delivery status in women with neuromyelitis optica spectrum disorder

Multiple Sclerosis and Related Disorders
Fereshteh AshtariNasrin Asgari

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is a potentially disabling disease which affects predominantly women of reproductive age. To evaluate the pre-pregnancy condition and to investigate the prevalence of obstetrical and neonatal complaints in NMOSD. An observational retrospective study of 37 NMOSD patients positive for aquaporin-4-immunoglobulin-IgG. Age at menarche, menstrual cycle, gravidity, type of delivery obstetrical complications and perinatal problems were recorded. We assessed the annualized relapse rate (ARR). A total of 23 patients (62%) suffered from irregular menstruations and two from infertility after disease onset. 11 patients had 20 informative pregnancies with 14 deliveries (5 cesareans) and six abortions, four spontaneous, and two ectopic pregnancies after the first trimester. Additionally, three patients experienced threatening abortion and one preeclampsia. No stillbirth or premature birth was recorded. None of the patients experienced attacks during pregnancy, but postpartum relapses occurred after 10 deliveries (71,4%) with the highest ARR (0.937; p = 0.037) during the first three months postpartum compared to pre-pregnancy ARR (0.375). Four patients (10.8%) developed the initial symptoms of NMO...Continue Reading

References

Aug 22, 2008·Immunological Investigations·Kristina M Adams Waldorf, J Lee Nelson
Aug 13, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samira SaadounMarios C Papadopoulos
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Yuko ShimizuKazuo Kitagawa
Jun 21, 2015·Neurology·Dean M WingerchukUNKNOWN International Panel for NMO Diagnosis
Nov 20, 2015·Neurology·Matthew M NourMaria Isabel Leite
May 3, 2016·Therapeutic Advances in Neurological Disorders·Nicolas Collongues, Jérôme de Seze
Jun 17, 2016·Acta neurologica Belgica·Ameneh Zare-ShahabadiSeyed Mohammad Baghbanian
Oct 21, 2016·Neurology. Neuroimmunology and Neuroinflammation·Vahid DavoudiTanuja Chitnis
Dec 27, 2016·Journal of the Neurological Sciences·Yanlu HuangWei Qiu
Apr 8, 2017·Mayo Clinic Proceedings·Brian G Weinshenker, Dean M Wingerchuk
Nov 3, 2017·Neurology·Eric C KlawiterBrian Weinshenker
Apr 18, 2018·Pediatric Rheumatology Online Journal·Nicole LingEmily von Scheven
Jul 27, 2018·Multiple Sclerosis and Related Disorders·Yanping TongYongping Fan
Aug 28, 2018·Multiple Sclerosis and Related Disorders·Guillermo Delgado-GarcíaJosé Flores-Rivera
Dec 24, 2018·Obstetric Medicine·Danielle WuebboltAhraaz Wyne
Mar 16, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Saif HudaAnu Jacob
Mar 21, 2019·Current Opinion in Neurology·Kazuo Fujihara
Jun 13, 2019·Brain and Behavior·Nasrin AsgariKirsten O Kyvik
Jun 20, 2019·Biomedicines·Marco A Lana-Peixoto, Natália Talim

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