Abstract
Carotid artery stenting (CAS) is a minimal invasive procedure used to resolve carotid occlusion that can be affected by peri-procedural complications. Statin use before CAS has shown to reduce peri-procedural risk and improve survival, though time-dependent cofactors that influence mortality has not been considered. The aim of this study was to evaluate long-term survival of patients who undergo CAS considering new occurred major adverse cardiovascular event (MACE) as time-dependent cofactor. In this study, 171 high cardiovascular risk patients (age 72 ± 8 years, 125 males) were enrolled after CAS procedure and were followed for a median of 8.4 years. Death occurred in 44% of patients with a mean time to death of 69 ± 39 months and MACE in 34% with a mean time of 35 ± 42 months. In patients who used or not statins at baseline, death occurred in 33% and 65%, respectively (p < 0.001). Survival analysis showed that statin use reduced risk of death (hazard ratio HR 0.36, 95% confidence interval CI 0.23⁻0.58, p < 0.0001). Including MACE as time-dependent variable did not change beneficial effects of statins. Additionally, statin use was associated with a protective effect on MACE (HR 0.48, 95% CI 0.27⁻0.85, p = 0.012); particularly,...Continue Reading
References
Dec 23, 1998·Atherosclerosis·J J BadimonV Fuster
Feb 13, 2002·Circulation·Albert W ChanStephen G Ellis
Jul 13, 2002·Journal of Clinical Ultrasound : JCU·Ivan N StaikovHeinrich P Mattle
Aug 12, 2005·Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·James KennedyThomas E Feasby
Jun 24, 2006·Radiology·Klaus GröschelAndreas Kastrup
Sep 29, 2007·Circulation·Lee A FleisherUNKNOWN Society for Vascular Surgery
Dec 18, 2007·Seminars in Vascular Surgery·Bruce A Perler
May 28, 2010·The New England Journal of Medicine·Thomas G BrottUNKNOWN CREST Investigators
Oct 22, 2010·Journal of Vascular Surgery·Fabio VerziniPiergiorgio Cao
Jun 5, 2012·Journal of Atherosclerosis and Thrombosis·Cristiana CatenaLeonardo A Sechi
Oct 24, 2012·Annals of Vascular Surgery·Rami O TadrosPeter L Faries
Mar 1, 2013·European Journal of Preventive Cardiology·Huseyin NaciA E Ades
Aug 1, 2013·International Journal of Epidemiology·Karen LeffondréPierre Joly
Oct 25, 2013·JAMA Surgery·George A AntoniouMiltos K Lazarides
Jun 13, 2014·Journal of Cardiovascular Medicine·Marco De CarloAlberto Balbarini
Sep 23, 2014·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T ReiffP A Ringleb
Sep 10, 2015·Stroke; a Journal of Cerebral Circulation·Jenifer H VoeksThomas G Brott
Feb 18, 2016·The New England Journal of Medicine·Kenneth RosenfieldUNKNOWN ACT I Investigators
Mar 25, 2016·Thrombosis and Haemostasis·Amirhossein SahebkarGianLuca Colussi
May 6, 2017·Journal of the American College of Cardiology·Partha SardarJay Giri
Jun 20, 2017·Stroke; a Journal of Cerebral Circulation·Jeong-Ho HongMoon-Ku Han
Oct 25, 2017·VASA. Zeitschrift für Gefässkrankheiten·Ralf Langhoff
Apr 21, 2018·JAMA : the Journal of the American Medical Association·Eliano P NavaresePaul A Gurbel
Jun 20, 2018·Journal of Vascular Surgery·Muhammad RizwanMahmoud B Malas
Jun 29, 2018·Vascular Pharmacology·Wenpei YuZhencheng Yan
Aug 14, 2018·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Pavlos TexakalidisDamianos G Kokkinidis
Citations
Sep 10, 2019·PloS One·Jihoon KangMoon-Ku Han
Jul 30, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Lingya QiaoXiaolin Xu
Apr 18, 2021·Journal of Vascular Surgery·Marios SagrisChristos Bakoyiannis
Jul 2, 2021·Clinical Neurology and Neurosurgery·Ayhan ErkolBurak Turan