Pre-synaptic function explains age-dependent actions of general anesthetics in the rat hippocampal synaptic transmission

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Koki HirotaMitsuaki Yamazaki

Abstract

Mechanisms by which age modifies general anesthetic requirements remain uncertain. In order to examine the age-related modification of general anesthetics in the central nervous system, we have studied the effects of thiopental and sevoflurane on hippocampal synaptic transmission in young and elderly rats. Field potentials of area CA1 were electrically elicited in hippocampal slices from young (4-month) and elderly (2-year) male Wistat rats. The effects of sevoflurane on both excitatory and inhibitory synaptic transmission were similar in the young and elderly preparations. In contrast, thiopental produced a greater effect on inhibitory synaptic transmission in young than elderly hippocampi, whereas the actions on excitatory synaptic transmission were negligible in both preparations. Corresponding experiments revealed (a) that the duration of recurrent inhibition was more prolonged by thiopental in young compared to elderly animals and (b) that thiopental enhanced the γ-amino-butyric acid (GABA) release from pre-synaptic terminals in an age-dependent manner. The thiopental actions on GABA discharge from pre-synaptic terminals appear to be responsible for the observed difference between young and elderly animals. The age-depende...Continue Reading

References

May 22, 1987·The Journal of Comparative Neurology·C A BarnesB L McNaughton
Mar 1, 1996·The European Journal of Neuroscience·C Papatheodoropoulos, G Kostopoulos
Jan 1, 1997·British Journal of Anaesthesia·K Hirota, S H Roth
May 1, 1997·Experimental Gerontology·H HarashimaD R Stanski
Feb 27, 1999·Toxicology Letters·K HirotaY Ito
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·C F Stevens, J H Williams
Jul 4, 2001·Nature Reviews. Neuroscience·D G Winder, J D Sweatt
Aug 24, 2004·Nature Reviews. Neuroscience·Uwe Rudolph, Bernd Antkowiak
Sep 18, 2004·Archives of Gerontology and Geriatrics·O MiyaishiK Isobe
Jul 5, 2005·Science·Greg Miller
Mar 23, 2007·European Journal of Anaesthesiology·M MäenpääH Scheinin

❮ Previous
Next ❯

Citations

Aug 27, 2013·Neurobiology of Learning and Memory·Lindsay A HohsfieldChristian Humpel
Jul 12, 2019·Journal of UOEH·Toshiko TanakaKentaro Kasai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.