PMID: 8960120Aug 1, 1996Paper

Pre-thymic transcription of TCR genes by adult murine bone marrow cells

Molecular Immunology
T G WangR Chervenak

Abstract

In the adult mouse, the earliest thymocytes are derived from bone marrow-resident T lymphocyte precursor (pre-T) cells that immigrate to the thymus. There they undergo maturation through a series of developmental steps that include rearrangement and expression of the TCR genes, positive and negative selection, and functional maturation. Although these intrathymic processes have been extensively characterized, little is known about the T cell-specific events that take place in the bone marrow microenvironment. Of particular interest are the events surrounding transcription and rearrangement of the various TCR chains that are required for functional TCR expression. We have previously reported the transcription of incompletely rearranged TCR beta genes in pre-T cell-containing fractions of adult bone marrow. Here we demonstrate that the TCR gamma chain genes are also transcriptionally active in these cells. Like the TCR beta transcripts, TCR gamma transcripts are sterile, originating from unrearranged gamma loci. Interestingly, both RAG-1 and RAG-2 transcripts were also detected in this cell fraction, suggesting that sterile TCR transcription might be dependent upon the presence of a functional recombinase system. However, both C ...Continue Reading

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Citations

Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·M EssandI Pastan
Mar 26, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mineui HongYoung-Hyeh Ko
Oct 27, 2007·Cellular Immunology·Hillary H NorrisRobert Chervenak

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