Pre-transplant blood transfusion and cyclosporin A induce long-term hamster cardiac xenograft survival in immunocompetent rats

P W VriensR C Robbins


In previous studies we have shown that pre-transplant hamster blood transfusion (HBT) can induce non-responsiveness in the T cell independent immunecompartment and result in tolerance towards hamster cardiac xenografts (Xgs) in T cell deficient athymic nude rats. In this study we test the combination of pre-transplant HBT with cyclosporin A (CSA) in immunocompetent Lewis rats. Before transplantation of a hamster cardiac Xg, 1 ml hamster blood was administered to nude rats or Lewis rats. CSA dissolved in olive oil was given orally at varying doses. Anti-hamster antibodies were measured by flowcytometry. In nude rats HBT 3 days before transplantation resulted in 100% long-term survival >100 days (n=9). In Lewis rats, HBT resulted in hyperacute rejection (HAR) (n=6). Treatment of nude rats with CSA at doses varying from five to 20 mg/kg/day and treatment of Lewis rats with CSA five or 10 mg/kg/day did not effect Xg survival. However, treatment of Lewis rats with CSA 20 mg/kg/day led to long-term survival of five of nine Xgs (p <0.01). Combination of HBT with CSA 10 mg/kg/day in Lewis rats resulted in long-term survival of four of seven Xgs. HBT and CSA 20 mg/kg/day resulted in 100% long-term survival (n=9). Immunoglobulin M (IgM) ...Continue Reading


Oct 1, 1976·Transplantation·G Opelz, P I Terasaki
Dec 1, 1992·Journal of the American Society of Nephrology : JASN·R L GellerJ L Platt
Jul 1, 1991·Transplantation·J van den BogaerdeD White
Nov 1, 1987·Transplantation·R E MichlerE A Rose
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Apr 1, 1987·Transplantation·M R KatzR R Lower
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Jun 1, 1982·Immunopharmacology·R H Yanagihara, W H Adler
Jan 1, 1994·Transplant Immunology·D A SteinbrüchelE Kemp
Nov 5, 1997·The Journal of Surgical Research·H LinS F Bolling
Mar 17, 1999·Transplantation Proceedings·B D Kahan

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Apr 6, 2005·Xenotransplantation·Reto M Baertschiger, Leo H Buhler

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