Pre-transplant gingival hyperplasia predicts severe cyclosporin-induced gingival overgrowth in renal transplant patients

Journal of Clinical Periodontology
E VargaL H Mair

Abstract

The relationship between the pre-transplant periodontal status and the development of post-transplant gingival overgrowth was investigated in a longitudinal study. The periodontal condition of 35 patients was examined on 2 occasions while they were on the transplant waiting list and then at 4-6, 10-12, 16 and 20 weeks post-transplant. At each visit the plaque index, the bleeding index and a pocket index (CPITN) were measured. Dental impressions were taken of the pre- and post-transplant gingival condition and used to make stone models which were used to score the gingival overgrowth index (GOI). The patients divided into 3 distinct groups having severe (n=13), mild (n=16) or no post-transplant gingival overgrowth (n=6). Only 1 of the patients had taken cyclosporin prior to inclusion into the study. All the patients who developed severe overgrowth had evidence of gingival hyperplasia before the transplant. There was no difference in the serum cyclosporin levels between the three groups (chi2<2.28, p>0.319). Furthermore, there was no statistical difference for any of the periodontal indices. This study indicates that the hyperplastic gingival inflammatory response of some individuals appears to be potentiated by cyclosporin resul...Continue Reading

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Citations

Mar 12, 2005·Journal of the American Academy of Dermatology·Pooja KheraJoseph C English
Dec 31, 2003·Transplantation Proceedings·H NowzariS Munroe
Sep 19, 2009·Clinical Rheumatology·Senol KobakEker Doganavsargil
Feb 21, 2003·Journal of Periodontology·Mônica AfonsoMaria Regina Sposto
Nov 26, 2004·Journal of Periodontology·Anna Dongari-Bagtzoglou, UNKNOWN Research, Science and Therapy Committee, American Academy of Periodontology
Apr 16, 2005·Journal of Periodontology·Aikaterini DoufexiEffie Ioannidou
Nov 5, 2008·Journal of Periodontology·Hsien-Chung ChiuEarl Fu
Jul 2, 2003·International Journal of Paediatric Dentistry·D ChabriaN M Kilpatrick
Jan 10, 2006·Periodontology 2000·Robin A Seymour
Dec 18, 2012·Periodontology 2000·M Cenk HaytacAngelo Mariotti
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Masatoshi KataokaToshihiko Nagata
Mar 9, 2000·Transplantation·D W ThomasG R Osborne
Feb 25, 2000·Australian Dental Journal·R I Marshall, P M Bartold
Feb 23, 2005·Journal of Dental Research·R ProctorS Porter
Jan 13, 2001·Periodontology 2000·R I GarciaE A Krall
Oct 1, 2004·Journal of Periodontology
May 8, 2002·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Kerri A Hood

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