Pre-Treatment and Post-Treatment Demodex Densities in Patients under Immunosuppressive Treatments

Medicina
Hacer KelesNilgun Senturk

Abstract

Background and Objectives: Demodex species are common obligatory parasites and normally present in low number in human beings. Immunosuppression was suggested to be associated with increased density of Demodex mites. Systemic glucocorticoids, cyclosporine, methotrexate, and azathioprine are commonly used immunosuppressive agents. We aim to determine the pre- and post-treatment Demodex densities in patients receiving immunosuppressive therapy and compare with those of healthy subjects. Materials and Methods: Demodex density was investigated at the beginning, first, and third months of the immunosuppressive therapy in 45 patients who received methotrexate, cyclosporine, systemic steroid, or azathioprine treatments and in 45 healthy subjects at the same time as the patients. Five standardized skin surface biopsies were taken from cheeks, forehead, nose, and chin of the patients and control group. The presence of five or more parasites in 1 cm2 area was considered as positive. Results: Demodex test was negative at the beginning of the treatment in all patients. Demodex test was positive in one patient in the first and third months of treatment and in three patients only in the third month of treatment. In the control group, Demodex...Continue Reading

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Citations

May 18, 2020·Journal of Personalized Medicine·Serkan Yüksel, Esra Pancar Yüksel
Sep 5, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Etty Bitton, Sarah Aumond
Mar 7, 2021·Pathogens·Ursula Fürnkranz, Julia Walochnik

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS

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