Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

BMC Cancer
Sheng HanAnhua Wu

Abstract

Markers of systemic inflammation are correlated with patient survival in various cancers. The prognostic value of neutrophil-to-lymphocyte ratio (NLR) was compared with that of platelet-to-lymphocyte ratio (PLR) in patients with glioblastoma. The association of NLR with neutrophil and T- cell infiltration was also explored. A total of 152 patients with glioblastoma were retrospectively analyzed. Clinical information was obtained from electronic medical records. Kaplan-Meier analysis and the Cox proportional hazards models were used to examine the survival function of pre-treatment NLR and PLR in these glioblastoma patients. Neutrophil and CD3(+) T-cell infiltration was assessed by immunohistochemical staining of tissue microarray cores from glioblastomas. Pre-treatment NLR levels were significantly correlated with overall survival (OS) in glioblastoma patients (multivariate hazard ratio =1.050; 95% confidence interval, 1.003-1.100; P = 0.037). Despite the correlation between NLR and PLR (R = 0.509, P < 0.001), NLR was superior to PLR as a prognostic factor. High pre-treatment NLR (≥4 versus < 4) was significantly associated with high neutrophil infiltration and low CD3(+) T-cell infiltration into tumors, and predicted poor OS (...Continue Reading

References

Sep 29, 1999·Acta Neuropathologica·G FossatiM L Rossi
Aug 10, 2000·Neurological Research·K IwatsukiT Hayakawa
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki NozawaDouglas Hanahan
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Mar 20, 2010·The Journal of Clinical Investigation·Jadwiga JablonskaSiegfried Weiss
Apr 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer LohrChristel Herold-Mende
Jun 29, 2011·British Journal of Neurosurgery·Young-Hee KimJe-Jung Lee
Jun 29, 2011·Anti-cancer Agents in Medicinal Chemistry·Richard E KastMarc-Eric Halatsch
Sep 21, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eyup BuyukkayaNihat Sen
Dec 25, 2012·Expert Review of Cardiovascular Therapy·Tariq BhatThomas Costantino
Jul 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Caleb RutledgeDaniel J Brat
Nov 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ji LiangJohn F de Groot
Jan 11, 2014·Journal of Neuro-oncology·Sevket BaltaCengiz Ozturk
May 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R StuppUNKNOWN ESMO Guidelines Working Group
Jun 11, 2014·Nature Reviews. Neurology·Wolfgang WickGuido Reifenberger
Dec 2, 2014·Neurosurgical Focus·Diane J AumAlbert H Kim
Mar 27, 2015·The Journal of Clinical Hypertension·Erdal BelenGüney Erdoğan
Oct 9, 2015·American Journal of Hypertension·Xing Liu, Kaijun Niu

❮ Previous
Next ❯

Citations

Jan 15, 2015·American Journal of Surgery·Joanna SzkanderaMartin Pichler
Nov 7, 2016·Clinical Neurology and Neurosurgery·Xing-Wang ZhouQing Mao
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Richard E KastMarc-Eric Halatsch
Nov 11, 2017·Frontiers in Immunology·Matteo MassaraRaffaella Bonecchi
Aug 31, 2017·Neurochemical Research·Georg Karpel-MasslerCarsten Bolm
Oct 6, 2017·Oncotarget·Samantha SemenkowPiotr Walczak
Aug 4, 2016·Oncotarget·Aurélie BertautFrancois Ghiringhelli
Sep 2, 2019·World Journal of Surgical Oncology·Yu-Ying LeiAi-Xia Sui
Jan 21, 2017·Molecular and Clinical Oncology·Masahide IkeguchiHiroaki Saito
Oct 28, 2017·Journal of Neuro-oncology·Marta LopesPaulo Linhares
Aug 30, 2018·Frontiers in Pharmacology·Peng-Fei WangChang-Xiang Yan
Jan 9, 2019·Frontiers in Immunology·Qianquan MaRong-Fu Wang
Nov 17, 2017·Journal of Neuro-oncology·Seema PatelMatthias A Karajannis
Nov 17, 2019·CNS Neuroscience & Therapeutics·Paulo LinharesRui Vaz
Jul 8, 2017·World Journal of Clinical Cases·Puneet GandhiSandeep Sorte
Sep 25, 2020·Scientific Reports·Xueran ChenZhiyou Fang

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
PCR
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.