Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Anne WolfHanns Häberlein

Abstract

Preparations of ivy leaves dry extract with secretolytic and bronchiolytic efficacy are widely used for the treatment of acute and chronic obstructive airway diseases. The mechanism by which ivy preparations improve lung functions is not fully understood. Here, we tested the influence of the three main saponins of ivy, α-hederin, hederacoside C and hederagenin, on the contraction and relaxation behaviour of isolated bovine tracheal smooth muscle strips by isometric tension measurements. None of the tested compounds altered histamine or methacholine-induced contraction of the smooth muscle strips. In contrast, the isoprenaline-induced relaxation of 100μM methacholine precontracted muscle strips was significantly enhanced when pre-treated with 1μM of α-hederin for 18h. The pre-treatment with hederacoside C or hederagenin had no effect on isoprenaline-induced relaxation. For the first time the bronchiolytic effect of α-hederin was demonstrated by isometric tension measurements using bovine tracheal smooth muscle strips. α-Hederin increases isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like methacholine.

Citations

Feb 24, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Janka Schulte-MichelsHanns Häberlein
Nov 26, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jan SeibelJutta Haunschild
Jan 1, 2013·Journal of Ethnopharmacology·Marta MendelMaria Wiechetek
Apr 17, 2012·Bioorganic & Medicinal Chemistry·Stefan BöttgerMatthias F Melzig
Apr 4, 2015·Yonsei Medical Journal·Kee Jae SongKyung-Su Kim
Jul 25, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaheed Ur RehmanHye Hyun Yoo

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