Pre-treatment with ozonized oxygen (O3) aggravates inflammation in septic rats

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
A TorossianA Bauhofer

Abstract

Ozone is produced by neutrophils during bacterial killing. Its application was found to be beneficial in peritonitis patients. Therefore, we measured survival and cytokines after ozone pre-treatment in septic rats. With approval, 40 male Wistar-rats were allocated to 1) ozone pre-treatment for five days before intra-abdominal sepsis, or 2) no pre-treatment. The primary endpoint was mortality at 120 h. Secondary endpoints were plasma cytokine levels. In the control group mortality was 50% (10/20 rats). After ozone pre-treatment, survival was only 35% (7/20 rats, Log-Rank test: P = 0.10). Ozone increased TNF-alpha and MIP-2 after infection: 127 +/- 23 pg/ml and 94 +/- 19 pg/ml (control group: 398 pg/ml and 369 pg/ml; P < 0.002 and P < 0.01). IL-6 levels were similar in both groups. Ozone pre-treatment was pro-inflammatory in sepsis with a trend to reduced survival. Therefore, its effects in sepsis should be further evaluated in animal trials.

Citations

Jan 15, 2011·International Journal of Medical Sciences·Levent YamanelAhmet Korkmaz
Dec 5, 2009·European Journal of Pharmacology·Clara Di FilippoMichele D'Amico
Dec 3, 2014·Enfermedades infecciosas y microbiología clínica·José L Martín-BarrasaM Teresa Tejedor-Junco

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