Pre-validation and inference in microarrays

Statistical Applications in Genetics and Molecular Biology
Robert Tibshirani, Brad Efron

Abstract

In microarray studies, an important problem is to compare a predictor of disease outcome derived from gene expression levels to standard clinical predictors. Comparing them on the same dataset that was used to derive the microarray predictor can lead to results strongly biased in favor of the microarray predictor. We propose a new technique called "pre-validation'' for making a fairer comparison between the two sets of predictors. We study the method analytically and explore its application in a recent study on breast cancer.

Citations

Aug 19, 2007·Médecine sciences : M/S·Géraldine LucchiPatrick Ducoroy
Jan 20, 2011·Briefings in Bioinformatics·Anne-Laure Boulesteix, Willi Sauerbrei
Dec 17, 2009·BMC Bioinformatics·Hege M BøvelstadOrnulf Borgan
Feb 11, 2010·BMC Bioinformatics·Anne-Laure Boulesteix, Torsten Hothorn
Nov 1, 2011·BMC Bioinformatics·Askar ObulkasimMark A van de Wiel
Apr 22, 2010·BMC Genomics·Glen C JicklingFrank R Sharp
Jun 28, 2011·BMC Medical Genomics·Muhammad G KibriyaHabibul Ahsan
Jun 28, 2011·Arthritis Research & Therapy·Piyanka E ChandraWilliam H Robinson
Apr 10, 2009·Genome Medicine·Anneleen DaemenBart De Moor
Feb 20, 2008·PLoS Computational Biology·Dennis Kostka, Rainer Spang
May 23, 2012·PLoS Computational Biology·Christof WinterRobert Grützmann
Nov 2, 2014·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Alexia KakourouBart Mertens
Dec 17, 2009·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger
Jan 13, 2006·Biometrics·Ross L PrenticeGarnet L Anderson
Oct 30, 2010·Annals of Neurology·Glen C JicklingFrank R Sharp
Oct 28, 2014·Statistics in Medicine·Gong ChenViswanath Devanarayan
Jul 1, 2014·International Journal of Cancer. Journal International Du Cancer·Kaushala JayawardanaJean Yee Hwa Yang
Aug 26, 2016·Journal of Biopharmaceutical Statistics·Michael C Sachs, Lisa M McShane
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Andrea N Goldstein-PiekarskiLeanne M Williams
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stefan WagerRobert J Tibshirani
Feb 2, 2017·Statistics in Medicine·Xin HuangViswanath Devanarayan
Mar 13, 2010·Bioinformatics·Kim-Anh Lê CaoGeoffrey J McLachlan
Aug 6, 2009·Statistical Methods in Medical Research·Daniela M Witten, Robert Tibshirani
Mar 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael E SeifertRoslyn B Mannon
Mar 24, 2012·Radiation Research·Vy LamJohn E Baker
Aug 26, 2016·Briefings in Bioinformatics·Fan ZhangMartin J Walsh
Nov 11, 2011·Science Translational Medicine·Andrew H BeckDaphne Koller
Dec 16, 2017·Journal of Cognitive Neuroscience·Andrea N Goldstein-PiekarskiMatthew P Walker

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biometrical Journal. Biometrische Zeitschrift
Rosa J Meijer, Jelle J Goeman
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Anneleen DaemenBart De Moor
© 2022 Meta ULC. All rights reserved