Preablation 131-I scans with SPECT/CT contribute to thyroid cancer risk stratification and 131-I therapy planning

The Journal of Clinical Endocrinology and Metabolism
Anca M AvramKa Kit Wong

Abstract

The use of preablation diagnostic radioiodine scans for risk stratification and radioiodine therapy planning for differentiated thyroid cancer (DTC) remains controversial. The objective was to assess the contribution of preablation diagnostic 131-I scans with SPECT/CT (Dx 131-I scan) to (1) the risk stratification and (2) the postoperative management of DTC. The study was designed as a prospective sequential patient series. The study was conducted at a University hospital. Three hundred twenty patients (pts) with DTC (219F; 101M, mean age 47.3 ± 16.4 y, range 10-90) were studied. Using clinical and histopathology information an endocrinologist performed risk stratification and determined postoperative management with respect to radioiodine therapy (RAI) planning. The decision to withhold or to administer RAI, and the recommended low, medium or high therapeutic 131-I activity were recorded. Dx 131-I scans were performed and interpreted by two nuclear medicine physicians as showing thyroid remnant, cervical nodal, or distant metastases. The endocrinologist then reperformed risk stratification and reformulated management after consideration of Dx 131-I scans and stimulated thyroglobulin (Tg) information. Main outcome measures were...Continue Reading

Citations

Feb 22, 2016·Seminars in Nuclear Medicine·Ravinder K GrewalHeiko Schöder
Jun 29, 2016·Journal of Endocrinological Investigation·M G CastagnaF Pacini
Oct 27, 2017·Healthcare·Rachel L RossDavid A Dorr
Jun 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariusz StasiołekAndrzej Lewiński
Jun 15, 2018·European Journal of Endocrinology·Domenico AlbanoRaffaele Giubbini
Oct 30, 2018·Clinical Nuclear Medicine·Anca M AvramDavid T Hughes
Jun 12, 2019·Thyroid : Official Journal of the American Thyroid Association·Douglas Van Nostrand
Apr 23, 2020·International Journal of Cancer. Journal International Du Cancer·Malik E JuweidFelix M Mottaghy
Feb 19, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Jérôme ClercDavid Taïeb
Mar 27, 2019·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Anca M Avram, Yuni K Dewaraja
Mar 23, 2018·Thyroid : Official Journal of the American Thyroid Association·Jessa E MillerDavid T Hughes
Jul 6, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Ora IsraelF Giammarile
Dec 16, 2017·Nuclear Medicine and Molecular Imaging·Sang-Woo Lee
Jun 28, 2018·Clinical Diabetes and Endocrinology·Corey J LagerAnca M Avram
Jun 7, 2020·Current Pharmaceutical Design·Einat Slonimsky, Mark Tulchinsky
May 4, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hao FuLibo Chen
Mar 4, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kevin J DonohoeJason A Wexler
May 3, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lin ChengLibo Chen
Jun 15, 2021·Frontiers in Endocrinology·Trynke van der BoomThera P Links

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