PMID: 6105295Jul 19, 1980Paper

Prealbumin as an index of liver function after acute paracetamol poisoning

Lancet
D R HutchinsonD V Parke

Abstract

Liver damage in a woman who had taken an overdose of paracetamol and dextropropoxyphene was assessed by monitoring serum prealbumin concentrations and by routine plasma enzyme determinations. The plasma aspartate aminotransferase returned to normal levels after 3 days, alkaline phosphatase was slow to show increases in activity, and serum albumin concentration was in the normal range throughout. Prothrombin-time, although initially very high, returned almost to normal as a result of the administration of plasma. In contrast, serum prealbumin concentration decreased significantly after 36 h and continued to decrease, showing the course of failing liver function, until the patient's death 15 days after presentation. Prealbumin, a functional plasma protein synthesised in the liver, has a short half-life, is a true index of liver function, and seems to be a more reliable indicator of liver function in drug overdose than plasma enzymes, prothrombin-time, or plasma drug concentration.

References

Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Feb 2, 1980·British Medical Journal·J B SaundersK O Lewis
Aug 13, 1965·Science·J H OPPEHNEIMERJ C SMITY

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Citations

Jul 18, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·D R HutchinsonD V Parke
Jan 1, 1987·Preparative Biochemistry·M M BashorJ W Neese
Oct 9, 2008·Canadian Journal of Physiology and Pharmacology·Hanumantha Rao Balaji Raghavendran, Periasamy Srinivasan
Sep 1, 1984·Revista Do Instituto De Medicina Tropical De São Paulo·N Manoukian, D R Borges
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·A W HallidayL H Blumgart
Apr 1, 1983·Journal of Applied Toxicology : JAT·M C Savides, F W Oehme
Jan 5, 2016·Biological & Pharmaceutical Bulletin·Syu-ichi KannoShin Yomogida
Mar 1, 1986·The Journal of Pharmacy and Pharmacology·D R HutchinsonD V Parke

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