PMID: 1538Nov 4, 1975

Prebiotic peptide-formation in the solid state. II. Reaction of glycine with adenosine 5'-triphosphate and P1,P2-diadenosine-pyrophosphate

Journal of Molecular Evolution
H SawaiL E Orgel


When a solution containing gly-N-pa and imidazole is evaporated to dryness and then maintained at a temperature between 65 degrees C and 100 degrees C, high yields of AppA and obligoglycines are obtained. We believe that ImpA is formed first, and then activates the carboxyl group of glycine or gly-A-pA. If glycine, ATP or AppA, and imidazole are heated together in the solid state, ImpA is formed and ATP , or indirectly from imidazole and gly-N-pA. Next the carboxyl group or glycine is activated by the ImpA formed in situ. The subsequent reactions of activated glycine leads to the formation of oligoglycines and the 2' (3')-glycylester of pA. Under plausible prebiobic conditions, good yields of oligoglycines up to the octamer can be obtained from glycine, ATP and imidazole.


Aug 17, 1973·Nature·R Lohrmann, L E Orgel
Aug 17, 1973·Nature·J J Flores, J O Leckie
Nov 29, 1974·Journal of Molecular Evolution·J T WardenM Calvin
Jan 1, 1973·Journal of Molecular Evolution·M Paecht-Horowitz, A Katchalsky
Apr 9, 1960·Nature·J Oró, C L GUIDRY


Nov 6, 2014·Life·Hussein Kaddour, Nita Sahai
Oct 1, 2018·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Izabela SibilskaJohn Yin
Aug 2, 1978·Journal of Molecular Evolution·A L Weber, L E Orgel
May 12, 1978·Journal of Molecular Evolution·A L Weber, L E Orgel
Jan 1, 1985·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·K Kobayashi, C Ponnamperuma
May 12, 1978·Journal of Molecular Evolution·R Lohrmann, L E Orgel
Jan 1, 1981·Journal of Molecular Evolution·J R Hawker, J Oró
Nov 23, 2017·Chembiochem : a European Journal of Chemical Biology·Raffaele SaladinoErnesto Di Mauro
Jan 1, 1982·Journal of Molecular Evolution·N Lahav, S Chang
Dec 1, 1980·Journal of Molecular Evolution·D H White, J C Erickson
Dec 18, 2007·Chemistry & Biodiversity·Bernd M RodeThomas Jakschitz
Oct 18, 2020·Scientific Reports·Kuhan ChandruH James Cleaves
Feb 27, 2020·Chemical Reviews·Moran Frenkel-PinterLuke J Leman
May 7, 2020·Chemical Reviews·Jessica C BowmanLoren Dean Williams

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