Prebiotic prevents impaired kidney and renal Oat3 functions in obese rats

The Journal of Endocrinology
Keerati WanchaiAnusorn Lungkaphin

Abstract

Obesity is health issue worldwide, which can lead to kidney dysfunction. Prebiotics are non-digestible foods that have beneficial effects on health. This study aimed to investigate the effects of xylooligosaccharide (XOS) on renal function, renal organic anion transporter 3 (Oat3) and the mechanisms involved. High-fat diet was provided for 12 weeks in male Wistar rats. After that, the rats were divided into normal diet (ND); normal diet treated with XOS (NDX); high-fat diet (HF) and high-fat diet treated with XOS (HFX). XOS was given daily at a dose of 1000 mg for 12 weeks. At week 24, HF rats showed a significant increase in obesity and insulin resistance associated with podocyte injury, increased microalbuminuria, decreased creatinine clearance and impaired Oat3 function. These alterations were improved by XOS supplementation. Renal MDA level and the expression of AT1R, NOX4, p67phox, 4-HNE, phosphorylated PKCα and ERK1/2 were significantly decreased after XOS treatment. In addition, Nrf2-Keap1 pathway, SOD2 and GCLC expression as well as renal apoptosis were also significantly reduced by XOS. These data suggest that XOS could indirectly restore renal function and Oat3 function via the reduction of oxidative stress and apopto...Continue Reading

References

Aug 17, 1999·Archives of Internal Medicine·B F CulletonD Levy
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·M GeisztT L Leto
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Jun 28, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K SrinivasanP Ramarao
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Jun 13, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Hua HongAlex F Chen
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Feb 1, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Alessandra Calábria BaxmannIta Pfeferman Heilberg
Dec 9, 2008·Molecular and Cellular Endocrinology·Abel Martin Garrido, Kathy K Griendling
Dec 1, 2004·Nutrition Research Reviews·Glenn R GibsonMarcel B Roberfroid
Jan 28, 2009·Clinical and Experimental Hypertension : CHE·Jun HuCarolyn M Ecelbarger
Feb 12, 2009·Clinical and Experimental Pharmacology & Physiology·Jeffrey E QuigleyJohn D Imig
Mar 2, 2010·The British Journal of Nutrition·Duraiswamy GobinathSiddalingaiya G Prapulla
Jan 5, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Joel D Kopple, Usama Feroze
Jun 21, 2011·International Journal of Molecular Sciences·Alba Fernández-SánchezJosé A Morales-González
Feb 18, 2012·American Journal of Physiology. Renal Physiology·Volker VallonTimo Rieg
Jul 31, 2012·Mutagenesis·Gholamreza FazeliNicole Schupp
Mar 9, 2013·The American Journal of the Medical Sciences·Arjinajarn PhatchawanLungkaphin Anusorn
May 4, 2013·Diabetes & Metabolism Journal·Bahram Pourghassem GargariMohammad Asghari Jafar-Abadi
Aug 21, 2013·Journal of the American Society of Nephrology : JASN·Kumar SharmaRobert K Naviaux
Apr 8, 2014·Cell Metabolism·Kacey J PrenticeMichael B Wheeler
Apr 29, 2014·The Journal of Nutritional Biochemistry·Alexandros PapadimitriouJosé B Lopes de Faria
Jul 25, 2014·The Journal of Toxicological Sciences·Wei-Jie WangChing-Sung Weng
Dec 6, 2014·Nature Reviews. Drug Discovery·Sanjay K Nigam
Dec 30, 2014·Physiological Reviews·Sanjay K NigamWei Wu
Dec 30, 2014·International Journal of Biological Macromolecules·Huijuan ZhangBaoguo Sun
Feb 11, 2015·World Journal of Nephrology·Salvador Lopez-Giacoman, Magdalena Madero
Jul 15, 2015·International Journal of Food Sciences and Nutrition·Zhaoping LiSydney M Finegold
Jul 22, 2016·The Journal of Biological Chemistry·Henry C LiuSanjay K Nigam
Jan 15, 2017·Nutrition·Natalie FriedliPhilipp Schuetz
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·M Kristina HamiltonHelen E Raybould
Apr 21, 2017·American Journal of Physiology. Cell Physiology·Young-Mee KimMasuko Ushio-Fukai

❮ Previous
Next ❯

Citations

May 28, 2019·European Journal of Nutrition·Sathima EaimworawuthikulSiriporn C Chattipakorn
Feb 18, 2020·Pflügers Archiv : European journal of physiology·Natalia Lucía Rukavina MikusicMarcelo Roberto Choi
Mar 23, 2021·Expert Opinion on Drug Metabolism & Toxicology·Adriana M TorresSanjay K Nigam
Feb 27, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Nattavadee PengrattanachotAnusorn Lungkaphin
Sep 30, 2021·European Journal of Clinical Nutrition·Amrita Vijay, Ana M Valdes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

The American Journal of the Medical Sciences
Arjinajarn PhatchawanLungkaphin Anusorn
Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Hiranya PintanaSiriporn C Chattipakorn
© 2022 Meta ULC. All rights reserved