Prebiotic synthesis of orotic acid parallel to the biosynthetic pathway

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
Y YamagataI Matsumoto

Abstract

By heating an aqueous solution of aspartic acid and urea, carbamylaspartic acid is first formed and then the molecule is cyclized to dihydroorotic acid (DHO) with loss of water. Irradiation of an aqueous solution of DHO with a tungsten lamp yields orotic acid by photo-dehydrogenation of the molecule. This pathway of orotic acid formation is quite similar to that of biosynthesis of the molecule.

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Citations

Mar 4, 2010·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Antonio Lazcano
Sep 24, 2009·Chemistry & Biodiversity·Marta Ruiz-BermejoSabino Veintemillas-Verdaguer
Mar 29, 2013·Chemistry : a European Journal·César Menor-Salván, Margarita R Marín-Yaseli
Jan 10, 2018·Nature Communications·Greg SpringsteenRamanarayanan Krishnamurthy
Jul 15, 2017·Chemistry : a European Journal·Eun-Kyong KimRamanarayanan Krishnamurthy
Jul 21, 2020·Chemical Reviews·Kamila B MuchowskaJoseph Moran
Mar 1, 1995·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A LazcanoJ Oró

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