Prebiotics and synbiotics: dietary strategies for improving gut health

Current Opinion in Gastroenterology
Janina A KrumbeckRobert W Hutkins

Abstract

A wide range of dietary carbohydrates, including prebiotic food ingredients, fermentable fibers, and milk oligosaccharides, are able to produce significant changes in the intestinal microbiota. These shifts in the microbial community are often characterized by increased levels of bifidobacteria and lactobacilli. More recent studies have revealed that species of Faecalibacterium, Akkermansia, and other less well studied members may also be enriched. We review the implications of these recent studies on future design of prebiotics and synbiotics to promote gastrointestinal health. Investigations assessing the clinical outcomes associated with dietary modification of the gut microbiota have shown systemic as well as specific health benefits. Both prebiotic oligosaccharides comprised of a linear arrangement of simple sugars, as well as fiber-rich foods containing complex carbohydrates, have been used in these trials. However, individual variability and nonresponding study participants can make the outcome of dietary interventions less predictable. In contrast, synergistic synbiotics containing prebiotics that specifically stimulate a cognate probiotic provide additional options for personalized gut therapies. This review describes ...Continue Reading

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Citations

Jun 3, 2016·Middle East Journal of Digestive Diseases·Shirin MoossaviAshraf Mohamadkhani
Oct 5, 2016·Middle East Journal of Digestive Diseases·Kamran B Lankarani
Jan 20, 2018·Annual Review of Food Science and Technology·Janina A KrumbeckRobert W Hutkins
Mar 5, 2019·Beneficial Microbes·V B M PetersM Meijerink
Oct 5, 2017·Plant Foods for Human Nutrition·Chanida Hansawasdi, Peter Kurdi
Feb 20, 2020·Beneficial Microbes·C D Quero CaleroP Manonelles Marqueta
May 1, 2018·Journal of Dairy Science·Zhaoxia WangYuyu Shao
May 28, 2017·Digestive Diseases and Sciences·Laura TassonRenzo Zanotti
Oct 17, 2017·Applied Microbiology and Biotechnology·Mario Cezar Rodrigues ManoGláucia Maria Pastore
Feb 16, 2021·Environmental Science and Pollution Research International·Yueping ChenYanmin Zhou
Feb 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mengyao ZhaoLiming Zhao

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