Prebiotics, probiotics and fecal microbiota transplantation in autism: A systematic review.

Revista de psiquiatrí́a y salud mental
Agustín Ernesto Martínez-González, Pedro Andreo-Martínez

Abstract

In recent years, there has been an increase in studies of the implications of the gut microbiota (GM) in children with autism spectrum disorder (ASD). There is a hypothesis which propose a relationship between the emotional state and the abundance of intestinal microbes through the so-called microbiota-intestine-brain axis. In this sense, dysbiotic GM could be a contributing factor to the appearance of ASD. This systematic review article analyzes the results of the intervention using prebiotics (carrot powder, vitamin A, partially hydrolyzed guar gum, galactooligosaccharides, etc.), probiotics (mainly: Lactobacillus, Bifidobacterium, etc.) and transplantation of fecal microbiota in ASD children. In conclusion, the results of the initial studies suggest changes in ASD symptoms, gastro-intestinal symptoms and GM composition after the interventions. However, the results should be taken with caution because there are very few studies that analyze the efficacy of long-term treatments and the different combinations of them.

Citations

Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Paulina ŻebrowskaŁukasz Łaczmański
May 6, 2021·Journal of Autism and Developmental Disorders·Pedro Andreo-MartínezAgustín Ernesto Martínez-González
Oct 29, 2021·Journal of Autism and Developmental Disorders·Agustín E Martínez-GonzálezJose A Piqueras

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