PMID: 15220663Jun 29, 2004Paper

Prebiotics promote good health: the basis, the potential, and the emerging evidence

Journal of Clinical Gastroenterology
J Van Loo

Abstract

The prebiotics concept, which was launched in 1995, concerns nondigested and selectively fermented carbohydrate food ingredients. It was thought that their effect in the colon could reduce risk for disease. The prebiotic concept is revisited and possible mechanisms are proposed. The physiologic consequences of prebiotic consumption are evaluated in terms of potential to reduce risk for disease. This is a compilation of several research papers, each of which complied with the World Medical Association Declaration of Helsinki. For human dietary intervention trials, the aim was to perform double-blind, placebo-controlled, cross-over studies. A parallel design was used only for long-term studies. Most research has been done with beta(2-1) fructans, so they are used as an example of prebiotics here. The results are relevant to the fields of gut function, lipid metabolism, mineral absorption, bone formation, immunology, and cancer. It is observed that modification of intestinal flora by inherently selectively fermented prebiotics is central in determining their nutritional properties. They interact positively through the large intestinal surface with various physiologic processes and are thought to improve health status by reducing r...Continue Reading

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Citations

Apr 21, 2007·The British Journal of Nutrition·Brigitta KleessenMonika Krueger
May 4, 2013·Nutrition Research Reviews·Elijah KiarieCharles M Nyachoti
May 15, 2016·Carbohydrate Polymers·Muhammad ShoaibSobia Niazi
Feb 9, 2007·Neonatal Network : NN·Susan Givens Bell
Mar 10, 2006·Current Infectious Disease Reports·Joshua Novak, Jeffry A Katz
Jun 15, 2005·European Journal of Oral Sciences·Jukka H Meurman
May 4, 2006·Inflammatory Bowel Diseases·Jeffry A Katz
Nov 28, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rachel D MoloneyJohn F Cryan
Jul 28, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Claude C RoyEmile Levy
Mar 20, 2019·Current Nutrition Reports·Monica C SerraOdessa Addison
Feb 18, 2016·Interdisciplinary Sciences, Computational Life Sciences·Sergio Olarte-AvellanedaOscar F Sánchez
May 1, 2021·Foods·Abigail Raffner BassonFabio Cominelli
Jun 2, 2009·Journal of Agricultural and Food Chemistry·Jannine K PattersonDennis D Miller

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