PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation

Annual Review of Physiology
J C Rekling, J L Feldman

Abstract

Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made In particular, a site in the ventrolateral medulla, the preBötzinger Complex, is hypothesized to contain neuronal circuits generating respiratory rhythm. Lesions or disruption of synaptic transmission within the preBötzinger Complex, either in vivo or in vitro, can abolish respiratory activity. Furthermore, the persistence of respiratory rhythm following interference with postsynaptic inhibition and the subsequent discovery of neurons with endogenous bursting properties within the preBötzinger Complex have led to the hypothesis that rhythmogenesis results from synchronized activity of pacemaker or group-pacemaker neurons.

References

Sep 1, 1975·Journal of Neurophysiology·D W RichterM Gabriel
Dec 1, 1992·Current Opinion in Neurobiology·D W RichterS Schwarzacher
Jan 1, 1992·Experimental Brain Research·M P Morin-SurunM Denavit-Saubié
Sep 11, 1992·Brain Research·C A ConnellyJ L Feldman
Dec 1, 1992·Brain Research Bulletin·H OnimaruK Iwatsuki
Feb 1, 1992·Journal of Applied Physiology·F G Issa, J E Remmers
Jul 1, 1991·Respiration Physiology·F T ZhangY R Li
Dec 1, 1990·Pflügers Archiv : European journal of physiology·H OnimaruI Homma
Aug 1, 1990·Respiration Physiology·R MonteauG Hilaire
Apr 8, 1990·The Journal of Comparative Neurology·H H Ellenberger, J L Feldman
Apr 1, 1990·Brain Research Bulletin·A ArataI Homma
Jan 1, 1989·Annals of the New York Academy of Sciences·J L Feldman, J C Smith
Sep 1, 1988·Journal of Applied Physiology·L FedorkoS J England
Jul 1, 1985·Acta Physiologica Scandinavica·K BudzińskaY Yamamoto
Jul 1, 1982·Pacing and Clinical Electrophysiology : PACE·B RonenS Feldman
Jun 15, 1995·The Journal of Physiology·J J GreerZ al-Zubaidy

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Citations

Jun 8, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Suguru KobayashiMamoru Aoki
Feb 3, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·B L DaviesB E Taylor
Feb 9, 2010·Cellular and Molecular Neurobiology·Guo-cai LiJing Cheng
Oct 12, 2012·Journal of Computational Neuroscience·Choongseok Park, Jonathan E Rubin
Jun 2, 2012·Journal of Biological Physics·Jan-Marino RamirezSebastien Zanella
Mar 11, 2009·Current Pain and Headache Reports·James M Walker, Robert J Farney
Nov 12, 2003·Respiratory Physiology & Neurobiology·Rachel E Winmill, Michael S Hedrick
Sep 7, 2005·Respiratory Physiology & Neurobiology·Guy LongobardoNeil S Cherniack
May 26, 2005·Respiratory Physiology & Neurobiology·Michael S Hedrick
Mar 31, 2004·Seminars in Neonatology : SN·Estelle B GaudaDaniel Kwak
Aug 30, 2000·Respiration Physiology·K F MorrisB G Lindsey
Sep 1, 2000·Respiration Physiology·B G LindseyR Shannon
Sep 1, 2000·Respiration Physiology·B E Taylor, K Lukowiak
Sep 1, 2000·Respiration Physiology·J DuffinJ H Peever
Sep 1, 2000·Respiration Physiology·A J Berger
Sep 29, 2000·Respiration Physiology·W M St-John, J F Paton
Apr 3, 2001·Respiration Physiology·M B Harris, W K Milsom
Jan 30, 2002·Trends in Neurosciences·Ole Kiehn, Matthew C Tresch
Dec 22, 2000·Progress in Neurobiology·Y Momose-SatoK Kamino
Oct 17, 1998·Progress in Neurobiology·S Iscoe
Sep 29, 1999·Progress in Neurobiology·E Nattie
Jun 14, 2000·Progress in Neurobiology·K BallanyiI Homma
Oct 26, 2002·Neuroscience Letters·Jijiang WangDavid Mendelowitz
Mar 10, 2001·Current Opinion in Neurobiology·E Marder
Jan 23, 1999·Current Opinion in Neurobiology·R L Calabrese
Sep 7, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R KinkeadG S Mitchell
Feb 9, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M S Hedrick, R D Morales
Feb 22, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·T WangE W Taylor
Dec 8, 2000·Autonomic Neuroscience : Basic & Clinical·M DutschmannJ F Paton
Jul 20, 2002·Respiratory Physiology & Neurobiology·Sophie AizenfiszJorge Gallego
Jul 11, 2002·Respiratory Physiology & Neurobiology·Mathias Dutschmann, Julian F R Paton
Sep 5, 2002·Respiratory Physiology & Neurobiology·Walter M St-John, Julian F R Paton
Jul 20, 2002·Respiratory Physiology & Neurobiology·Irene C Solomon, Jay B Dean

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