PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

ELife
Clément MenuetAndrew M Allen

Abstract

Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated centrally, with respiratory neurons entraining the activity of pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of optogenetic inhibition and excitation in vivo and in situ in rats, as well as neuronal tracing, we demonstrate that preBötzinger Complex (preBötC) neurons, which form the kernel for inspiratory rhythm generation, directly modulate cardiovascular activity. Specifically, inhibitory preBötC neurons modulate cardiac parasympathetic neuron activity whilst excitatory preBötC neurons modulate sympathetic vasomotor neuron activity, generating heart rate and blood pressure oscillations in phase with respiration. Our data reveal yet more functions entrained to the activity of the preBötC, with a role in generating cardiorespiratory oscillations. The findings have implications for cardiovascular pathologies, such as hypertension and heart failure, where respiratory entrainment of heart rate is diminished and respiratory entrainment of blood pressure exaggerated.

References

Nov 1, 1990·The American Journal of Physiology·P G GuyenetT A Riley
Mar 15, 1996·The Journal of Physiology·N Koshiya, P G Guyenet
Mar 1, 1996·Journal of Neuroscience Methods·J F Paton
Sep 23, 2003·Journal of Neurocytology·G F AlheidD R McCrimmon
May 25, 2004·Journal of Applied Physiology·Evguenia BouairiDavid Mendelowitz
Feb 21, 2006·The European Journal of Neuroscience·Shun-ichi KuwanaKunihiko Obata
Mar 11, 2006·The Journal of Physiology·Daniel A Mandel, Ann M Schreihofer
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
May 16, 2009·Current Hypertension Reports·Paolo Palatini, Stevo Julius
Aug 1, 2009·Respiratory Physiology & Neurobiology·Thomas E DickKendall F Morris
Mar 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Consuelo Morgado-ValleJack L Feldman
May 11, 2010·Respiratory Physiology & Neurobiology·Olga DergachevaDavid Mendelowitz
May 14, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E W TaylorN Skovgaard
Aug 4, 2010·Nature Neuroscience·Julien BouvierGilles Fortin
Jun 1, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Antonio Merico, Marianna Cavinato
Jan 13, 2012·The Journal of Comparative Neurology·Charles P SevignyAndrew M Allen
Jun 29, 2012·The Journal of Comparative Neurology·Belinda R BowmanAnn K Goodchild
Oct 19, 2012·Journal of Neurophysiology·Michael S CarrollJan-Marino Ramirez
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hidehiko KoizumiJeffrey C Smith
Apr 30, 2013·Nature·Jeffrey D MooreDavid Kleinfeld
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davi J A MoraesBenedito H Machado
Apr 22, 2014·Progress in Brain Research·Thomas E DickKendall F Morris
Nov 8, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clément MenuetAndrew M Allen
May 27, 2015·The Journal of Physiology·Zaki AlsahafiSilvia Pagliardini
Oct 29, 2015·The Journal of Physiology·Linford J B BriantJulian F R Paton
Apr 5, 2016·Neuron·Martin DeschênesDavid Kleinfeld

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Citations

Sep 24, 2020·Journal of Neurophysiology·Lauren S SegersBruce G Lindsey
May 1, 2021·International Journal of Environmental Research and Public Health·Kai KisielinskiOliver Hirsch
Apr 20, 2021·The Journal of Physiology·Davi J A MoraesJulian F R Paton
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G PfurtschellerG Schwarz
Jul 6, 2021·Respiratory Physiology & Neurobiology·Elenia CinelliFulvia Bongianni
Nov 11, 2021·Physiological Reports·Leonel F Pérez-AtencioLuis C Barrio

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