Precancerous Gastric Lesions with Helicobacter pylori vacA+ /babA 2+ /oipA+ Genotype Increase the Risk of Gastric Cancer

BioMed Research International
Theeraya Simawaranon BartphoChavaboon Dechsukhum

Abstract

The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of Helicobacter pylori (H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of cagA, vacA, iceA2, babA2, and oipA genes and their association with clinical outcomes. Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of cagA, vacA, iceA2, babA2, and oipA genes and their association with clinical outcomes. H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of. H. pylori), host genetic susceptibility, and host immune responses. This study investigated the presence of vacA, babA2, and oipA genes and their association with clinical outcomes. vacA, babA2, and oipA genes and their association with clinical outcomes. P=0.033, OR = ...Continue Reading

References

Jan 1, 1966·Scandinavian Journal of Gastroenterology·M SiuralaM Wiljasalo
Jul 3, 1998·Gastroenterology·L J van DoornW Quint
May 21, 1999·Science·A CovacciR Rappuoli
Feb 13, 2001·Infection and Immunity·D T PrideM J Blaser
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Hiroshi OhataMasao Ichinose
Apr 8, 2004·Journal of Gastroenterology·Takeshi Azuma
Aug 6, 2004·The Journal of Infectious Diseases·Jenni K BoonjakuakulJay V Solnick
Mar 11, 2005·Nature Reviews. Microbiology·Timothy L Cover, Steven R Blanke
Jul 26, 2005·Infection and Immunity·Jenni K BoonjakuakulJay V Solnick
Jan 18, 2008·Cancer Research·Aime T FrancoRichard M Peek
Mar 18, 2008·Journal of Clinical Gastroenterology·Nayoung KimIn Sung Song
Apr 17, 2008·International Journal of Cancer. Journal International Du Cancer·Masami SuganumaHirota Fujiki
May 25, 2010·Nature Reviews. Cancer·D Brent Polk, Richard M Peek
Oct 12, 2010·Clinical Microbiology Reviews·Lydia E WroblewskiKeith T Wilson
Aug 24, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·John T LohTimothy L Cover
Aug 25, 2012·Frontiers in Cellular and Infection Microbiology·Samuel L PalframanKipros Gabriel
May 22, 2013·ISRN Gastroenterology·Tamer EssawiMohammad A Farraj
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jul 24, 2014·Future Oncology·Yoshio Yamaoka, David Y Graham
Sep 18, 2014·Postȩpy higieny i medycyny doświadczalnej·Monika Maria BiernatBarbara Iwańczak
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Saeed Mahboubi AghdamAhad Khalilnezhad
Feb 7, 2015·Microbial Pathogenesis·Loghman SalimzadehHedayatollah Shirzad
Apr 9, 2015·Journal of Cancer Prevention·Yo Han Park, Nayoung Kim
Oct 17, 2015·Expert Review of Gastroenterology & Hepatology·Muhammad Miftahussurur, Yoshio Yamaoka
Nov 28, 2015·Helicobacter·Seyedeh Zahra BakhtiFarideh Siavoshi
Apr 24, 2016·Biomedical Journal·Cheng-Yen KaoJiunn-Jong Wu
May 20, 2017·Pakistan Journal of Medical Sciences·Fehmida BibiEsam I Azhar
Aug 16, 2017·Scientific Reports·Omid TeymournejadAmin Talebi Bezmin Abadi
Sep 13, 2017·Journal of Clinical and Diagnostic Research : JCDR·Maryam SohrabiAbdollah Bazargani
Feb 3, 2018·Canadian Journal of Gastroenterology & Hepatology·Kianoosh DadashzadehAkyala Ishaku Adamu
Feb 23, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Evariste Tshibangu KabambaYoshio Yamaoka

❮ Previous
Next ❯

Citations

Jan 14, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Omolbanin FeiliAbbas Yazdanbod
May 1, 2021·Cancers·Manikandan PalrasuAlexander I Zaika

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
Polymerase Chain Reaction
PCR

Software Mentioned

SPSS
Light Cycler 480

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.