Precedent fluctuation of serum hs-CRP to albumin ratios and mortality risk of clinically stable hemodialysis patients

PloS One
Jyh-Chang HwangCharn-Ting Wang

Abstract

A high sensitivity C-reactive protein to albumin ratio (hs-CRP/Alb) predicts mortality risk in patients with acute kidney injury. However, it varies dynamically. This study was conducted to evaluate whether a variation of this marker was associated with long-term outcome in clinically stable hemodialysis (HD) patients. hs-CRP/Alb was checked bimonthly in 284 clinically stable HD outpatients throughout all of 2008. Based on the "slope" of trend equation derived from 5-6 hs-CRP/alb ratios for each patient, the total number of patients was divided into quartiles--Group 1: β≦ -0.13, n = 71; group 2: β>-0.13≦0.003; n = 71, group 3: β>0.003≦0.20; and group 4: β>0.20, n = 71. The observation period was from January 1, 2009 to August 31, 2012. Group 1+4 showed a worse long-term survival (p = 0.04) and a longer 5-year hospitalization stay than Group 2+3 (38.7±44.4 vs. 16.7±22.4 days, p<0.001). Group 1+4 were associated with older age (OR = 1.03, 95% CI = 1.01-1.05) and a high prevalence of congestive heart failure (OR = 2.02, 95% CI = 1.00-4.11). Standard deviation (SD) of hs-CRP/Alb was associated with male sex (β = 0.17, p = 0.003), higher Davies co-morbidity score (β = 0.16, p = 0.03), and baseline hs-CRP (β = 0.39, p<0.001). Patient...Continue Reading

References

Nov 1, 1980·Intensive Care Medicine·E Domínguez de VillotaM I Tomás
Aug 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S J DaviesG I Russell
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Y YeunG A Kaysen
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vandana MenonMark J Sarnak
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamyar Kalantar-ZadehJoel D Kopple
Jan 9, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bruce A CooperCarol A Pollock
Jan 22, 2005·Seminars in Dialysis·Burl R Don, George Kaysen
Mar 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George TsirpanlisChrysoula Nicolaou
Feb 29, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincenzo PanichiUNKNOWN RISCAVID Study Group
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sunna SnaedalPeter Bárány
Dec 18, 2009·Kidney International·Daniela V BarretoUNKNOWN European Uremic Toxin Work Group (EUTox)

❮ Previous
Next ❯

Citations

Apr 22, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideki WadaHiroyuki Daida
Dec 2, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bruno RanchinJustine Bacchetta

❮ Previous
Next ❯

Software Mentioned

SPSS
Excel

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

© 2021 Meta ULC. All rights reserved