Prechemotherapy Touch Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer

Oncology
Xin Shelley WangCharles S Cleeland

Abstract

We examined the emergence of chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting toxicity of oxaliplatin, over the course of oxaliplatin-based chemotherapy for colorectal cancer (CRC). Predicting which patients will likely develop CIPN is an ongoing clinical challenge. Oxaliplatin-naïve patients with CRC underwent quantitative sensory testing (QST) before beginning oxaliplatin-based chemotherapy and then rated CIPN-related symptoms via the MD Anderson Symptom Inventory (MDASI) weekly for 26 weeks. Mixed modeling examined the value of QST for predicting higher CIPN (MDASI numbness/tingling) during treatment. Trajectory analysis identified a patient subgroup with consistently higher CIPN symptoms. Numbness/tingling was the most frequent, most severe symptom, with 51% of patients clustering into a high CIPN subgroup. Touch sensation deficits (Bumps Detection test) significantly predicted the development of more severe numbness/tingling [estimate (est) = 0.106, p = 0.0003]. The high CIPN subgroup reported increased pain (est = 0.472, p < 0.0001) and interference with walking (est = 0.840, p < 0.0001). In the high CIPN subgroup, patient-reported numbness/tingling worsened rapidly in weeks 0-5 (est = 0.57, p < 0.0001) ...Continue Reading

Associated Clinical Trials

Citations

Mar 4, 2017·The Journal of Pain : Official Journal of the American Pain Society·Shannon M SmithJames Witter
May 22, 2018·Clinical Journal of Oncology Nursing·Grace Campbell, Marjorie A Skubic
Dec 3, 2017·Pain and Therapy·Vasiliki BrozouPanagiotis Zis
Jul 13, 2017·Current Opinion in Supportive and Palliative Care·Elaine G Boland, Sam H Ahmedzai
Jul 15, 2017·Current Opinion in Anaesthesiology·Peggy Y Kim, Carrie E Johnson
Apr 15, 2020·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Grace A Kanzawa-Lee
Mar 20, 2019·Cancers·Helen L EdwardsMichael I Bennett
Mar 24, 2020·F1000Research·Richard Gordon-Williams, Paul Farquhar-Smith
Aug 7, 2021·Journal of Personalized Medicine·Roser VelascoAndreas A Argyriou

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