Precious GEMMs: emergence of faithful models for ovarian cancer research

The Journal of Pathology
Sarah Stuckelberger, Ronny Drapkin

Abstract

The development of Genetically Engineered Mouse Models (GEMMs) has catalyzed tremendous progress in cancer research. However, it has been difficult to design adequate mouse models for high-grade serous carcinoma (HGSC), the most common and lethal form of ovarian cancer. The genetic complexity of the disease, as well as the recent appreciation that most HGSCs arise from the fallopian tube (FT) secretory epithelium rather than the ovarian surface epithelium, has stifled the development of robust GEMMs. In a recent issue of this journal, Zhai et al presented an elegant mouse model for ovarian cancer that uses Ovgp1 as an FT-specific promoter to inactivate Brca1, Trp53, Rb1, Nf1, and Pten. The authors showed that loss of these genes in the mouse FT epithelium can mimic the different stages of human HGSC tumorigenesis. Their robust model emphasizes the importance of considering both the cell of origin and tumor genetics in developing accurate model systems. They provide a useful tool for studying mechanisms of disease in vivo and for research into novel methods of prevention, early detection, and treatment of HGSC. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Citations

Nov 15, 2018·Cancers·Jaeyeon KimRobert C Bast
Jun 13, 2019·Biology of Reproduction·David P Cook, Barbara C Vanderhyden
Feb 2, 2020·Scientific Reports·Marcia de Almeida Monteiro Melo FerrazNucharin Songsasen
Mar 22, 2020·Pharmacology & Therapeutics·Hunter D Reavis, Ronny Drapkin
May 1, 2021·Genome Medicine·Da PengPatrick Cahan
Sep 16, 2020·Seminars in Cancer Biology·Olivia Le SauxS Intidhar Labidi-Galy

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