Precipitated kappa-opioid receptor agonist withdrawal increase glutamate in rat locus coeruleus

European Journal of Pharmacology
K HoshiI K Ho

Abstract

Extracellular fluid levels of excitatory amino acids (glutamate, Glu; and aspartate, Asp) in the locus coeruleus and the behavioral signs during naloxone-precipitated withdrawal from kappa-opioid receptor agonists, butorphanol and (5 alpha, 7 alpha, 8 beta) -(+)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4,5]dec-8-yl]-be nzaneacetamide (U-69,593), were investigated by in vivo microdialysis. Increases in levels of Glu, but not of Asp, were noted after naloxone (12 or 48 nmol/5 microliters, locus coeruleus)-precipitated withdrawal in the rats which had been intracerebroventricularly infused with butorphanol (26 nmol/1 microliters/h) or U-69,593 (26 nmol/10 microliters/h) for 3 days. The Glu levels in the locus coeruleus increased following administration of naloxone before and during the first 15-min sample after the precipitation of withdrawal in the butorphanol- or U-69,593-dependent rats. Furthermore, behavioral evidence of withdrawal (teeth-chattering, wet-dog shakes, etc.) was detected following the naloxone challenge in the butorphanol- and U-69,593-infused rats, but not in saline-infused controls. These results provide direct evidence to support the role of excitatory amino acids within the locus coeruleus in butorphanol or...Continue Reading

References

Oct 22, 1991·European Journal of Pharmacology·P Horan, I K Ho
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 26, 1995·European Journal of Pharmacology·M MosaddeghiD Paul
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Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K YasudaG I Bell

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Citations

May 16, 2000·Journal of Biomedical Science·R W RockholdI K Ho
Aug 26, 1998·European Journal of Pharmacology·H Zhu, I K Ho
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·S SinchaisukR W Rockhold
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Oct 7, 1998·Progress in Neurobiology·N Singewald, A Philippu
Mar 28, 1998·Japanese Journal of Pharmacology·H ZhuI K Ho
Sep 4, 2007·Brain Research·Nigel C NoriegaHenryk F Urbanski
Nov 15, 2008·The Journal of Comparative Neurology·B A S ReyesE J van Bockstaele

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