PMID: 6160381Aug 29, 1980Paper

Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites

Molecular and Cellular Biochemistry
M Z Atassi

Abstract

Intensive research in the author's laboratory had culminated in the determination and synthesis of all the antigenic sites of myoglobin in 1975 and of lysozyme in 1978. Very recently most of the antigenic sites of serum albumin were also localized and synthesized. These investigations provided the first unique insight into the molecular features responsible for the immune recognition of protein antigens and of the factors which determine and regulate the antigenicity of the sites. But moreover, these studies have charted a multi-approach chemical strategy for investigation and synthetic duplication of protein binding sites. Furthermore, the concept of 'surface-simulation' synthesis, which we introduced and developed during our determination of the antigenic structure of lysozyme, has provided a remarkable dimension of unlimited versatility for the synthetic mimicking of any type of protein binding sites. In this concept, the spatially adjacent residues of a protein binding site are linked directly via peptide bonds with appropriate spacers into a single peptide which does not exist in the protein but mimicks a surface region of it. This has proved to be a powerful concept in protein molecular recognition and has opened up many ...Continue Reading

References

May 9, 1978·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A E Romero-HerreraA E Friday
Jan 1, 1975·Advances in Immunology·M Reichlin
Jan 1, 1978·Advances in Experimental Medicine and Biology·R Jemmerson, E Margoliash
Jan 1, 1978·Advances in Experimental Medicine and Biology·E BenjaminiD M Rennick
Jan 1, 1978·Advances in Experimental Medicine and Biology·M Z Atassi, A L Kazim
Jan 1, 1978·Advances in Experimental Medicine and Biology·E H Eylar
Aug 1, 1978·Immunochemistry·M Z Atassi, J A Smith
Jan 1, 1979·CRC Critical Reviews in Biochemistry·M Z Atassi
Oct 2, 1979·Biochemistry·L G Chavez, H A Scheraga
Jan 1, 1978·Immunochemistry·A L Kazim, M Z Atassi
May 1, 1978·The Biochemical Journal·M Z Atassi, C L Lee
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L M AmzelF F Richards
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D M SegalD R Davies
Nov 6, 1973·Biochemistry·M SchifferA B Edmundson
Dec 1, 1973·European Journal of Immunology·I MelchersD C Shreffler
Jan 1, 1969·Immunochemistry·M Z Atassi, D J Skalski

❮ Previous
Next ❯

Citations

May 1, 1989·Molecular Immunology·R AstonG L Ada
Oct 1, 1989·Journal of Neuroimmunology·D S GregersonL A Donoso
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P K BhatnagarG N Vyas
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E C DeFreitasH Koprowski
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B Mulac-JericevićM Z Atassi
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M Z AtassiG S Bixler
Dec 1, 1992·Immunological Reviews·M ZanettiR Billetta
Aug 1, 1985·Immunological Investigations·E M AllenN J Calvanico
Jan 1, 1993·International Reviews of Immunology·R Billetta, M Zanetti
Jan 1, 1984·Immunological Communications·R P Pelley
Jun 1, 2011·Allergy·R C Aalberse, R Crameri
Jun 1, 1984·Immunological Reviews·N K Jerne
Dec 13, 2000·Journal of Molecular Recognition : JMR·R H MeloenJ W Slootstra
Jan 30, 1992·Nature·M Zanetti
Jun 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·P H EhrlichR E Canfield
Dec 31, 2004·Immunological Investigations·Basak Kayhan, Cemalettin Aybay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.