Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration

Biomaterials
Zhengjie LinKelvin Wai Kwok Yeung

Abstract

A range of magnesium ions (Mg2+) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device. The PLGA-MgO sponge-like spherical core works as a reservoir of Mg2+ while the alginate shell serves as physical barrier to control the outflow of Mg2+ at ∼50 ppm accurately for 2 weeks via its adjustable surface micro-porous network. With the aid of controlled release of Mg2+, the new core-shell microsphere system can effectively enhance osteoblastic activity in vitro and stimulate in-situ bone regeneration in vivo in terms of total bone volume, bone mineral density (BMD), and trabecular thickness after operation. Interestingly, the Young's moduli of formed bone on the core-shell microsphere group have been restored to ∼96% of that of the surrounding matured bone. These findin...Continue Reading

Citations

Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haotian PanXiaodong Cao
Jun 5, 2020·Journal of Biomedical Materials Research. Part a·Yuyin JiangXuebin Zheng
May 22, 2020·Frontiers in Pharmacology·Yunfan ZhangBing Han
Oct 28, 2019·Frontiers in Bioengineering and Biotechnology·Hassan RammalHalima Kerdjoudj
Aug 28, 2020·Journal of Periodontology·Wei HeJiaxuan Qiu
Oct 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min GeJun Yang
May 18, 2020·Journal of Biomedical Materials Research. Part a·Akhil PatelShilpa Sant
Oct 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tzu-Cheng SungQingsong Ye
Nov 3, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sheng LiLing Xiao
Dec 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ling-Kun ZhangYan-Qing Guan
Jan 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rui ChenJian-Dong Yuan
Feb 25, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinyun ZhaiWilliam Weijia Lu
Apr 9, 2021·Acta Biomaterialia·Shue JinJidong Li
Apr 28, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingyue LiuJinglei Wu
May 6, 2021·Advanced Healthcare Materials·Chang XieHongwei Ouyang
Jul 20, 2021·ACS Biomaterials Science & Engineering·Sung-Min KangShuichi Takayama
Dec 25, 2019·ACS Applied Materials & Interfaces·Ehsan Nazarzadeh ZarePooyan Makvandi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.