Precisely parameterized experimental and computational models of tissue organization

Integrative Biology : Quantitative Biosciences From Nano to Macro
Jared M MolitorisAndre Levchenko

Abstract

Patterns of cellular organization in diverse tissues frequently display a complex geometry and topology tightly related to the tissue function. Progressive disorganization of tissue morphology can lead to pathologic remodeling, necessitating the development of experimental and theoretical methods of analysis of the tolerance of normal tissue function to structural alterations. A systematic way to investigate the relationship of diverse cell organization to tissue function is to engineer two-dimensional cell monolayers replicating key aspects of the in vivo tissue architecture. However, it is still not clear how this can be accomplished on a tissue level scale in a parameterized fashion, allowing for a mathematically precise definition of the model tissue organization and properties down to a cellular scale with a parameter dependent gradual change in model tissue organization. Here, we describe and use a method of designing precisely parameterized, geometrically complex patterns that are then used to control cell alignment and communication of model tissues. We demonstrate direct application of this method to guiding the growth of cardiac cell cultures and developing mathematical models of cell function that correspond to the u...Continue Reading

References

Aug 1, 1968·Experimental Cell Research·T R Elsdale
Feb 1, 1994·Journal of Cardiovascular Electrophysiology·M S Spach, M E Josephson
Feb 1, 1997·Cardiovascular Research·V G Fast, A G Kléber
Dec 3, 1998·IEEE Transactions on Bio-medical Engineering·D C Latimer, B J Roth
Jul 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D K JonesM A Horsfield
May 24, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Junjie ChenXin Yu
Jun 5, 2003·Chaos·Natalia TrayanovaFelipe Aguel
Aug 12, 2005·Annals of the New York Academy of Sciences·Patrick HelmRaimond L Winslow
Dec 13, 2005·Circulation Research·Patrick A HelmRaimond L Winslow
Mar 28, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mladen J KocicaFrancisco Torrent-Guasp
Aug 31, 2006·Biotechnology Journal·Ruei-Zeng LinHwan-You Chang
Nov 23, 2006·Journal of the American College of Cardiology·Partho P SenguptaBijoy K Khandheria
May 8, 2007·Progress in Biophysics and Molecular Biology·Miguel Valderrábano
Nov 30, 2007·PLoS Biology·HoJung ChoAndre Levchenko
Jul 8, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gernot PlankNatalia A Trayanova
Dec 20, 2008·Molecular Systems Biology·Zhizhong YinAndre Levchenko
May 6, 2009·Biophysical Journal·Nima Badie, Nenad Bursac
Sep 29, 2011·Biophysical Journal·Kathleen S McDowellNatalia A Trayanova
Aug 10, 2012·Lancet·Barry J Maron, Martin S Maron
Apr 6, 2013·The Nurse Practitioner·Kathleen T Hickey, Kevin Rezzadeh
Mar 1, 2012·Cardiovascular Engineering and Technology·V HariharanH Huang
Feb 27, 2014·Indian Heart Journal·Olujimi A AjijolaKalyanam Shivkumar
Apr 8, 2015·PLoS Computational Biology·Nancy K DrewAnna Grosberg
Jun 1, 1976·Wilhelm Roux's Archives of Developmental Biology·Tom Elsdale, Frances Wasoff

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Citations

Jul 15, 2016·Journal of Medicinal Chemistry·Chiara BorsariMaria Paola Costi
Oct 28, 2016·Journal of Biomechanical Engineering·Nancy K DrewAnna Grosberg
May 20, 2020·Science Advances·Taras TurivOleg D Lavrentovich
Dec 6, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Vassilios J BezzeridesWilliam T Pu
Oct 20, 2018·Frontiers in Physiology·Alfonso Bueno-Orovio
Nov 25, 2019·Cell Systems·Ashley R G LibbyTodd C McDevitt

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