Precision and accuracy of commercial laboratories' ability to classify positive and/or negative allergen-specific IgE results

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
S L SzeinbachP B Williams

Abstract

Accurate and reliable evaluation of the presence or absence of allergen-specific IgE is important in the differential diagnosis of allergic disease. A variety of different commercial tests are available for this purpose. There are few data available to judge how the results of these different tests compare with one another in everyday use. To examine prospectively the extent of comparability among specific IgE results from different laboratories. Six diagnostic laboratories employing five different methods to assay specific IgE were selected. Aliquots from 26 serum samples that contained variable levels of IgE specific to 17 common aeroallergens were sent in triplicate to each study laboratory during a 6-week time period. Results were reported numerically and by class scores and then compared by examining their concordance using Kendall's W nonparametric statistical test. In addition, cut-off values were compared by a best agreement analysis using reported results. Reproducibility was determined using precision profiles based upon the coefficient of variation among triplicates for each allergen across the range of reported results. In all, 7,813 tests were analyzed. Concordance among different assays in commercial use with one ...Continue Reading

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Citations

Sep 3, 2003·Clinical Biochemistry·Mario Plebani
Jul 27, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Robert A WoodP Brock Williams
Sep 3, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sheryl L SzeinbachHanaa Elhefni
Jan 1, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P Brock Williams
Aug 29, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Thomas M Li
Jul 25, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·P Brock WilliamsJay Portnoy
Dec 19, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Staffan AhlstedtHans Perborn
May 10, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R G Hamilton
Oct 20, 2011·Journal of the National Cancer Institute·Federico C F CalboliDominique S Michaud
Feb 5, 2008·The Journal of Allergy and Clinical Immunology·Julie WangHugh A Sampson
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Jan 28, 2004·Otolaryngologic Clinics of North America·Ivor A Emanuel
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Apr 17, 2016·Immunology and Allergy Clinics of North America·Justin Greiwe, Jonathan A Bernstein
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Mar 21, 2016·Clinical Biochemistry·Karina Rodríguez-CapoteTrefor N Higgins
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