Precision Epitaxy for Aqueous 1D and 2D Poly(ε-caprolactone) Assemblies

Journal of the American Chemical Society
Maria C ArnoRachel K O'Reilly

Abstract

The fabrication of monodisperse nanostructures of highly controlled size and morphology with spatially distinct functional regions is a current area of high interest in materials science. Achieving this control directly in a biologically relevant solvent, without affecting cell viability, opens the door to a wide range of biomedical applications, yet this remains a significant challenge. Herein, we report the preparation of biocompatible and biodegradable poly(ε-caprolactone) 1D (cylindrical) and 2D (platelet) micelles in water and alcoholic solvents via crystallization-driven self-assembly. Using epitaxial growth in an alcoholic solvent, we show exquisite control over the dimensions and dispersity of these nanostructures, allowing access to uniform morphologies and predictable dimensions based on the unimer-to-seed ratio. Furthermore, for the first time, we report epitaxial growth in aqueous solvent, achieving precise control over 1D nanostructures in water, an essential feature for any relevant biological application. Exploiting this further, a strong, biocompatible and fluorescent hydrogel was obtained as a result of living epitaxial growth in aqueous solvent and cell culture medium. MC3T3 and A549 cells were successfully en...Continue Reading

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Citations

Dec 12, 2017·Chemistry, an Asian Journal·Johannes C Brendel, Felix H Schacher
Aug 10, 2018·Macromolecular Rapid Communications·Menandro CruzMitchell A Winnik
Jul 27, 2018·Chemistry : a European Journal·Charles Jarrett-WilkinsIan Manners
Mar 27, 2020·Chemical Communications : Chem Comm·Shaofei SongMitchell A Winnik
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enrique FolgadoMona Semsarilar
Mar 22, 2018·Nature Communications·Gerald GuerinMitchell A Winnik
Oct 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tomoki NishimuraKazunari Akiyoshi
Sep 22, 2020·Chemical Science·Osama El-ZubirAndrew Houlton
Apr 15, 2021·Journal of the American Chemical Society·Yifan ZhangIan Manners
Jun 25, 2021·Chemical Science·Liam MacFarlaneIan Manners
Feb 6, 2018·Journal of the American Chemical Society·Jiangping XuMitchell A Winnik
Jan 29, 2019·Journal of the American Chemical Society·Jeffrey C FosterRachel K O'Reilly
Jul 1, 2020·Journal of the American Chemical Society·Huda ShaikhIan Manners
Aug 14, 2020·Journal of the American Chemical Society·Tomoya FukuiIan Manners
Jul 10, 2018·Journal of the American Chemical Society·Danny BousmailHanadi F Sleiman
Nov 20, 2018·Journal of the American Chemical Society·Alex M OliverIan Manners
Sep 3, 2021·Journal of the American Chemical Society·Zhengmin TangShaoliang Lin
Aug 25, 2021·Angewandte Chemie·Geyu LinHuibin Qiu

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Methods Mentioned

BETA
NMR
transmission electron microscopy
electron diffraction
confocal microscopy
rheology

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