Precision genome engineering through adenine and cytosine base editing

Nature Plants
Jin-Soo Kim

Abstract

Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR-Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.

References

Dec 3, 2009·Genome Research·Hyung Joo LeeJin-Soo Kim
Apr 3, 2014·Nature Reviews. Genetics·Hyongbum Kim, Jin-Soo Kim
Sep 1, 2015·Nature Methods·Jeff VierstraJohn A Stamatoyannopoulos
Oct 20, 2015·Nature Biotechnology·Je Wook WooJin-Soo Kim
Nov 1, 2016·Nature Methods·Gaelen T HessMichael C Bassik
Mar 1, 2017·Nature Biotechnology·Kyoungmi KimJin-Soo Kim
Mar 28, 2017·Nature Biotechnology·Zenpei ShimataniAkihiko Kondo
Apr 12, 2017·Nature Biotechnology·Daesik KimJin-Soo Kim
Aug 8, 2017·Nature·Hong MaShoukhrat Mitalipov

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Citations

Apr 17, 2018·Human Molecular Genetics·Cui ZhangJinfu Wang
Apr 5, 2019·Molecular Diagnosis & Therapy·Petros PatsaliCarsten W Lederer
Apr 9, 2019·Plant Biotechnology Journal·Katsuya NegishiSeiichi Toki
Jun 28, 2019·Plant Biotechnology Journal·Alan H SchulmanTeemu H Teeri
Jul 17, 2019·Nature Plants·Yingxiao ZhangYiping Qi
Dec 7, 2018·BMC Plant Biology·Masahiro NishiharaKeisuke Tasaki
Jan 10, 2019·Nature Communications·Puping LiangZhou Songyang
Oct 17, 2019·Plant Biotechnology Journal·Yaling ZhaoTong Zhang
Sep 5, 2020·Microbial Cell Factories·Zhenquan LiuDawei Zhang
Apr 29, 2019·Cellular and Molecular Life Sciences : CMLS·Zhiquan LiuLiangxue Lai
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kangquan Yin, Jin-Long Qiu
Jul 30, 2019·Frontiers in Plant Science·Tanushri KaulPawan Kumar Agrawal
Dec 25, 2019·Science China. Life Sciences·Yawei ZhaoYinhua Lu
Jun 19, 2020·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·V V Santosh KumarViswanathan Chinnusamy
Jan 4, 2021·Cellular and Molecular Life Sciences : CMLS·Yu-Fan ChuangGuei-Sheung Liu
Nov 15, 2020·The Journal of Biological Chemistry·Philip D Kiser, Krzysztof Palczewski
Dec 16, 2020·BMC Biology·Nicholas BrookhouserDavid A Brafman
Jan 13, 2021·The Journal of Biological Chemistry·Philip D Kiser, Krzysztof Palczewski
Apr 27, 2021·Plant Communications·Yingxiao ZhangYiping Qi
Nov 26, 2019·ACS Synthetic Biology·Xiuqing XinXueli Zhang
Aug 14, 2021·Molecular Plant·Lisha Shen, Hao Yu

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Methods Mentioned

BETA
deamination
gene knockout
allow gene knock-in
Digenome-seq
the

Software Mentioned

Digenome
BE

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