PMID: 86376Apr 14, 1979

Precision in estimating gestational age and its influence on sensitivity of alphafetoprotein screening

British Medical Journal
C J RobertsW P Ennis


The interpretation of maternal serum alpha-fetoprotein (AFP) concentrations in relation to fetal neural tube defects depends on accurate assessment of the gestational age. In a quadruple-blind study three antenatal methods of assessment--namely, menstrual dates, clinical examination, and ultrasound scanning--were correlated with postnatal assessment using the Dubowitz scoring system. The best agreement to +/- 1 week was obtained using menstrual dates and ultrasound in combination, such agreement being found in 91 (77%) of the 118 women studied. Since serum AFP concentrations vary with gestational age, precise gestational dating is necessary. In many cases, particularly in women who are unsure of their dates or have irregular menstrual cycles, ultrasound examination is needed to supplement clinical findings.


Dec 16, 1978·Lancet·M J BennettG V Chamberlain
Jul 1, 1970·The Journal of Pediatrics·L M DubowitzC Goldberg
Jun 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·S Campbell, G B Newman


Dec 12, 1981·British Medical Journal·M J Brindle
Sep 1, 1983·Journal of Epidemiology and Community Health·D WatsonK Costeloe
Dec 1, 1985·Journal of Medical Genetics·K M LaurenceC J Roberts
Dec 1, 1979·Lancet·G Delle FaveA Kohn
Dec 1, 1979·Lancet·G M Raab
May 1, 1985·British Journal of Obstetrics and Gynaecology·M H HallM L Samphier
Jan 26, 1985·British Medical Journal·B M HibbardK M Laurence

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