Precision Light for the Treatment of Psychiatric Disorders

Neural Plasticity
Sevag Kaladchibachi, Fabian Fernandez


Circadian timekeeping can be reset by brief flashes of light using stimulation protocols thousands of times shorter than those previously assumed to be necessary for traditional phototherapy. These observations point to a future where flexible architectures of nanosecond-, microsecond-, and millisecond-scale light pulses are compiled to reprogram the brain's internal clock when it has been altered by psychiatric illness or advanced age. In the current review, we present a chronology of seminal experiments that established the synchronizing influence of light on the human circadian system and the efficacy of prolonged bright-light exposure for reducing symptoms associated with seasonal affective disorder. We conclude with a discussion of the different ways that precision flashes could be parlayed during sleep to effect neuroadaptive changes in brain function. This article is a contribution to a special issue on Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders curated by editors Shimon Amir, Karen Gamble, Oliver Stork, and Harry Pantazopoulos.


Sep 1, 1979·Neuroscience Letters·G M VaughanA de la Peña
Jan 1, 1978·Scandinavian Journal of Gastroenterology·A C WicksK W Heaton
Apr 1, 1989·Biological Psychiatry·Michael TermanB Perlman
Jan 1, 1988·Journal of Biological Rhythms·Norman E RosenthalT A Wehr
Sep 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C J BojkowskiJ Arendt
Jan 16, 1987·Science·A J LewyT M Hoban
Feb 1, 1985·The Journal of Experimental Zoology·D Joshi, M K Chandrashekaran
Sep 1, 1972·The Journal of Comparative Neurology·R Y Moore, N J Lenn
Jul 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·H J Lynch
Jan 1, 1970·Pflügers Archiv : European journal of physiology·R A Wever
Jan 1, 1969·Pflügers Archiv : European journal of physiology·J AschoffR A Wever
Nov 1, 1983·Neuroendocrinology·B D Goldman, J M Darrow
Oct 1, 1983·Psychiatry Research·D F KripkeD Janowsky
Jan 1, 1984·Archives of General Psychiatry·Norman E RosenthalT A Wehr
May 1, 1984·The Journal of Experimental Zoology·D Joshi, M K Chandrashekaran
Jan 1, 1983·Pflügers Archiv : European journal of physiology·R A WeverC M Wildgruber
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J S TakahashiM Menaker
Nov 1, 1982·The American Journal of Psychiatry·A J LewyT A Wehr
Dec 12, 1980·Science·A J LewyS P Markey
Jan 1, 1994·Journal of Biological Rhythms·D B BoivinCharles A Czeisler
Feb 1, 1995·Pharmacology & Therapeutics·D Healy, J M Waterhouse
Aug 1, 1994·Biological Psychiatry·D H AveryA L Kazaras
Jan 1, 1993·The American Journal of Psychiatry·D H AveryD L Dunner
Dec 1, 1995·The American Journal of Psychiatry·R W LamR T Joffe
Jan 1, 1996·Behavioural Brain Research·R Y Moore
Jan 10, 1998·Photochemistry and Photobiology·Till Roenneberg, Russell G Foster
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·Ignacio ProvencioMark D Rollag
Feb 17, 1998·The American Journal of Psychiatry·A O Kogan, P M Guilford
Apr 29, 1998·Annals of Medicine·D Dawson, C J van den Heuvel
Aug 4, 1998·The American Journal of Physiology·A N Van Den PolH Craig Heller
Oct 23, 1998·Archives of General Psychiatry·C I EastmanP M Meaden
Oct 23, 1998·Archives of General Psychiatry·A J LewyJ M Jackson
Feb 25, 1999·Journal of Intellectual Disability Research : JIDR·E M Dykens, A C Smith
Mar 19, 1999·Neuroscience Letters·A Arvanitogiannis, S Amir
Jun 3, 1999·Acta Psychiatrica Scandinavica·T M Lee, C C Chan
Dec 10, 1999·Chronobiology International·C H Johnson
Dec 10, 1999·The Journal of Clinical Psychiatry·Michael Terman, Jiuan Su Terman
Jun 14, 2000·Journal of Medical Genetics·Lorraine PotockiJames R Lupski
Aug 2, 2000·The Journal of Physiology·Jamie M ZeitzerCharles A Czeisler
Apr 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·S M WilemanS A Naji
Jun 16, 2001·Journal of Biological Rhythms·T J BartnessG E Demas
Jul 11, 2001·The Journal of Pediatrics·Hélène De LeersnyderA Munnich
Aug 22, 2001·Biological Psychiatry·D H AveryP N Prinz
Sep 18, 2001·The Journal of Physiology·T A WehrWallace C Duncan
Nov 17, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Russell G Foster, C Helfrich-Förster
Feb 9, 2002·Science·David M BersonMotoharu Takao
Dec 14, 2002·Science·Norman F RubyBruce F O'Hara
Mar 8, 2003·Journal of Neuroendocrinology·Christian CajochenAnna Wirz-Justice
Mar 26, 2003·Nature Genetics·Rebecca E SlagerS H Elsea
Jun 26, 2003·The Journal of Clinical Psychiatry·Francesco BenedettiEnrico Smeraldi
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Steven W LockleyCharles A Czeisler
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·M FINGERMAN
Jan 1, 1960·Science·P J DE COURSEY
Nov 22, 1963·Science·R J WURTMANL S PHILLIPS
Mar 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·W B QUAY
Apr 24, 2004·The Cochrane Database of Systematic Reviews·A TuunainenT Endo
May 8, 2004·Chronobiology International·Stéphanie Perreau-LenzAndries Kalsbeek
Apr 1, 1996·International Journal of Obstetric Anesthesia·R Kan
Apr 1, 2005·The American Journal of Psychiatry·Robert N GoldenCharles B Nemeroff
Sep 17, 2005·Biological Psychiatry·Gena GlickmanGeorge C Brainard
Dec 13, 2005·Brain Research Reviews·Lawrence P Morin, C N Allen
Sep 15, 1958·Proceedings of the National Academy of Sciences of the United States of America·C PittendrighP Kaus
May 12, 2006·Chronobiology International·Kurt KräuchiAnna Wirz-Justice
Aug 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seithikurippu R Pandi-PerumalLeonid Kayumov
Aug 8, 2006·Trends in Endocrinology and Metabolism : TEM·Hélène De Leersnyder
Dec 8, 2006·The American Journal of Psychiatry·Michael Terman, Jiuan Su Terman
Mar 14, 2007·Current Opinion in Neurology·Andrea L GropmanAnn C M Smith
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luis Vidal, Lawrence P Morin
Oct 24, 2007·Journal of Affective Disorders·Christian EvenFrédéric Rouillon
Oct 30, 2007·Sleep Medicine Reviews·Michael Terman
Sep 23, 2008·Journal of Affective Disorders·Kathryn RoeckleinIgnacio Provencio
Feb 12, 2009·Acta Psychiatrica Scandinavica·J L AndersonSteven W Lockley
Jun 18, 2009·Glia·Martin Krueger, Ingo Bechmann
Sep 15, 2009·Trends in Cognitive Sciences·Gilles VandewalleDerk-Jan Dijk
Feb 13, 2010·Annual Review of Physiology·Charna DibnerUrs Albrecht
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Aug 4, 2010·Journal of Biological Rhythms·Michael Terman, Jiuan Su Terman
Sep 30, 2010·Journal of Biological Rhythms·Till RoennebergMartha Merrow
Oct 29, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Gonzalo LajeAnn C M Smith
Jul 9, 2011·American Journal of Medical Genetics. Part a·Philip M BooneLorraine Potocki
Jul 16, 2011·PloS One·Jamie M ZeitzerH Craig Heller
Aug 4, 2011·Neuropsychobiology·Gerald PailSiegfried Kasper
Dec 14, 2011·The Journal of Clinical Endocrinology and Metabolism·Marta NovákováAlena Sumová
May 23, 2012·Handbook of Clinical Neurology·Anna Wirz-Justice, Michael Terman
Jul 7, 2012·Experimental Neurology·Lawrence P Morin
Jan 11, 2013·Physiological Reviews·Kristin Eckel-Mahan, Paolo Sassone-Corsi
Jan 16, 2013·Parkinson's Disease·Sonja RuttenYsbrand D van der Werf
Jul 3, 2013·Psychiatry Research·Kathryn RoeckleinPeter Franzen
Sep 18, 2014·Journal of Biological Rhythms·Jamie M ZeitzerH Craig Heller
Dec 2, 2014·Neuroscience Letters·Laurence KocherBruno Claustrat
May 6, 2015·Journal of Affective Disorders·Björn MårtenssonLisa Ekselius
Nov 13, 2015·The Cochrane Database of Systematic Reviews·Barbara NussbaumerGerald Gartlehner
Nov 26, 2015·Sleep Medicine Reviews·Annette van MaanenFrans J Oort
Feb 9, 2016·The Journal of Clinical Investigation·Raymond P Najjar, Jamie M Zeitzer
Nov 9, 2016·Psychiatry Research·Scott A LaurenzoJess G Fiedorowicz
Apr 14, 2017·JCI Insight·Shadab A RahmanElizabeth B Klerman
May 27, 2017·ELife·Shanaz DiesslerPaul Franken
Aug 29, 2017·Current Sleep Medicine Reports·Mariana G Figueiro


Sep 21, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Maria KormanAndrew N Coogan
May 28, 2020·Frontiers in Neurology·Bo JinShuang Wang

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Mental Disorders
Circadian Rhythms
Treatment Protocols
Mood Disorders
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