Precision medicine for the treatment of severe pneumonia in intensive care

Expert Review of Respiratory Medicine
Jordi Rello, Antonio Perez

Abstract

Despite advances in its management, community-acquired pneumonia (CAP) remains the most important cause of sepsis-related mortality and the reason for many ICU admissions. Severity assessment is the cornerstone of CAP patient management and the attempts to ensure the best site of care and therapy. Survival depends on a combination of host factors (genetic, age, comorbidities, defenses), pathogens (virulence, serotypes) and drugs. To reduce CAP mortality, early adequate antibiotic therapy is fundamental. The use of combination therapy with a macrolide seems to improve the clinical outcome in the subset of patients with high inflammation due to immunomodulation. Guidelines on antibiotic therapy have been associated with beneficial effects, and studies of newer adjunctive drugs have produced promising results. This paper discusses the current state of knowledge regarding of precision medicine and the treatment of severe CAP patients.

References

Aug 1, 1991·The American Review of Respiratory Disease·A TorresR Rodriguez-Roisin
Aug 1, 1990·The American Review of Respiratory Disease·J PachonA Verano
Jan 23, 1997·The New England Journal of Medicine·M J FineW N Kapoor
Dec 24, 1997·JAMA : the Journal of the American Medical Association·T P MeehanJ M Fine
Jun 19, 1998·BMJ : British Medical Journal·P McQuillanC H Collins
May 1, 1993·Respiratory Medicine·C M Tang, J T Macfarlane
Oct 14, 1998·American Journal of Respiratory and Critical Care Medicine·S EwigA Torres
Aug 18, 1999·The American Journal of Medicine·M A Mufson, R J Stanek
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·M ConfalonieriG Umberto Meduri
Dec 28, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·R BenensonE Williams
Apr 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C JokinenP H Mäkelä
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Aug 30, 2001·Archives of Internal Medicine·G W WatererR G Wunderink
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Derek C AngusWishwa N Kapoor
Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·José A MartínezJosep Mensa
Apr 2, 2003·The Journal of Antimicrobial Chemotherapy·Jorge Roig, Jordi Rello
Jul 12, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor L YuUNKNOWN International Pneumococcal Study Group
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Silvia Fernández-SerranoFrederic Manresa
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·Miquel FerrerAntoni Torres
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph F PlouffeDouglas B Schwartz
Jan 30, 2004·The New England Journal of Medicine·Sébastien GibotPierre-Edouard Bollaert
Apr 14, 2004·Chest·Jordi AlmirallUNKNOWN Community-Acquired Pneumonia Maresme Study Group
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Larry M BaddourUNKNOWN International Pneumococcal Study Group
Jun 11, 2004·Chest·Gene L ColiceHoward G Birnbaum
Nov 16, 2004·The American Journal of Medicine·Eric M MortensenJacqueline Pugh
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Marco ConfalonieriG Umberto Meduri
Dec 22, 2004·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·K WeissJ Tremblay
Jan 25, 2005·International Journal of Antimicrobial Agents·Evangelos J Giamarellos-BourboulisHelen Giamarellou
Mar 23, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E García VázquezA Torres
Apr 6, 2005·The American Journal of Medicine·Drahomir AujeskyMichael J Fine
Jun 7, 2005·American Journal of Respiratory and Critical Care Medicine·Rosario MenéndezUNKNOWN NEUMOFAIL Group
Jun 16, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Li-Cher LohTarmizi Thayaparan
Sep 16, 2005·Chest·Miquel SabriàUNKNOWN Legionnaires Disease Therapy Group
Sep 17, 2005·Journal of Internal Medicine·C MuellerA P Perruchoud

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Citations

Apr 28, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jordi RelloUNKNOWN members of ESGCIP, ID-IRI Network
Sep 30, 2016·Expert Review of Clinical Pharmacology·Jordi RelloAntonio Perez
Jan 10, 2017·Current Opinion in Infectious Diseases·Davide Leoni, Jordi Rello
May 10, 2017·Expert Opinion on Pharmacotherapy·Mario CazzolaMaria Gabriella Matera
Oct 13, 2017·Advances in Therapy·Jordi RelloSilvia Moyano
Jan 24, 2019·Expert Review of Anti-infective Therapy·Jan J De Waele, Sofie Dhaese
Feb 20, 2020·Advances in Therapy·João Ferreira-CoimbraJordi Rello

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