Precision medicine in cholangiocarcinoma

Translational Gastroenterology and Hepatology
Antonio PellinoLuca Fabris

Abstract

Cholangiocarcinoma is one of the epithelial cancers with the poorest prognosis and the narrowest therapeutic choice in humans. Compared with other cancer types, cholangiocarcinoma has been often neglected by oncology and liver research studies, thereby leaving many issues unsolved. Apart from the early and marked aggressiveness, one of the main reasons of the still unsatisfying clinical management of cholangiocarcinoma is its wide tumor heterogeneity needing more than other diseases a 'precision medicine' approach. In this regard, in the last few years there has been an awakening of interest aimed at dissecting the complex molecular and genomic profile of cholangiocarcinoma. Thus, a range of molecular players have been recently identified as putative mechanistic determinants of cholangiocarcinoma invasiveness, encompassing tyrosine kinase receptors, metabolic enzymes, transcription factors, small GTPases, ubiquitin ligases, and chromatin-remodelling proteins, whose aberrant expression may derive from stochastic mutations as well as from pro-oncogenic paracrine signals released by the stromal microenvironment, which is particularly exuberant in cholangiocarcinoma. Herein, we sought to overview the most relevant observations unra...Continue Reading

Citations

Mar 21, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Jorge AdevaJuan W Valle
Mar 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Luca FabrisMario Strazzabosco
Apr 25, 2020·Cells·Samantha SarcognatoMaria Guido
May 31, 2020·Drugs·Sheridan M Hoy
May 25, 2020·Virchows Archiv : an International Journal of Pathology·Jeremy AugustinDominique Wendum
Mar 8, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Luca ViganoGuido Torzilli
Dec 13, 2018·BioMed Research International·Gang HuCheng-Yuan Liu
Feb 25, 2021·Expert Opinion on Investigational Drugs·Massimiliano CadamuroLuca Fabris
Apr 18, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Gizem Kayki-Mutlu, Martin C Michel
Aug 28, 2021·International Journal of Molecular Sciences·Christopher Fabian MaierSebastian Schölch
Jul 18, 2019·Visceral Medicine·Aline GottliebAli Canbay

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