Precision medicine in circadian rhythm sleep-wake disorders: current state and future perspectives

Personalized Medicine
Henry KeijzerLeopold Mg Curfs

Abstract

In circadian rhythm sleep-wake disorders precision medicine is less developed than in other medical disciplines mainly because homeostatic sleep and circadian timing have a very complex phenotype with multiple genetic regulation mechanisms. However, biomarkers, phenotyping and psychosocial characteristics are increasingly used. Devices for polysomnography, actigraphy and sleep-tracking applications in mobile phones and other consumer devices with eHealth technologies are increasingly used. Also sleep-related questionnaires and the assessment of co-morbidities influencing sleep in circadian rhythm sleep-wake disorders are major contributors to precision sleep medicine. To further strengthen the (pharmaco-)genetic and biomarker pillar, technology needs to be evolved further. Routinely measuring treatment results using patient-reported outcome measures and clinical neurophysiological instruments will boost precision sleep medicine.

References

Jan 17, 1975·Science·H J LynchM H Ho
Oct 1, 1992·Chronobiology International·A J LewyR L Sack
Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·A J Lewy, D A Newsome
Dec 12, 1980·Science·A J LewyS P Markey
Jun 24, 2000·Nature·A D Roses
Feb 22, 2001·Science·J C VenterX Zhu
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Jul 14, 2001·Clinical Pharmacology and Therapeutics·S HärtterL Bertilsson
Jan 5, 2002·Behaviour Research and Therapy·Linda HarveyColin A Espie
Aug 23, 2003·Journal of Psychosomatic Research·Constantin R SoldatosThomas J Paparrigopoulos
Jan 15, 2005·Sleep Medicine Reviews·Josephine Arendt, Debra Jean Skene
Aug 27, 2005·Journal of Sleep Research·Helen J Burgess, Charmane I Eastman
Aug 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seithikurippu R Pandi-PerumalLeonid Kayumov
Dec 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Laurent SeugnetPaul J Shaw
Mar 21, 2007·Cellular and Molecular Life Sciences : CMLS·M Kimura, J Winkelmann
Aug 19, 2007·Sleep·Silvia SookoianCarlos Jose Pirola
Oct 9, 2007·Sleep Medicine·Konstanze DiefenbachIvar Roots
Nov 22, 2008·Journal of Sleep Research·Anne Marie Meijer
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dana K Mirick, Scott Davis
Jul 21, 2009·Nature Reviews. Neuroscience·Chiara Cirelli
Aug 26, 2009·Current Drug Metabolism·Shu-Feng ZhouWei Duan
Feb 6, 2010·Sleep Medicine·Carla R JungquistMichael L Perlis
Jun 26, 2010·Journal of Intellectual Disability Research : JIDR·W BraamLeopold M G Curfs
Oct 28, 2010·Current Opinion in HIV and AIDS·Kyle Strimbu, Jorge A Tavel
Dec 2, 2010·Sleep·Ingeborg M van GeijlswijkMarcel G Smits
Mar 4, 2011·Journal of Behavior Therapy and Experimental Psychiatry·Elissa MyersDaniel Freeman
Apr 13, 2011·Clinical Psychology Review·Geneviève BellevilleMarie-Ève St-Pierre-Delorme
May 24, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Henry KeijzerJacqueline M T Klein Gunnewiek
Sep 2, 2011·Current Opinion in Pulmonary Medicine·Fernando M S CoelhoBrian J Murray
Dec 14, 2011·Journal of Medical Internet Research·Julia E W C van Gemert-PijnenErwin R Seydel

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Software Mentioned

DLMO
WikiPathways

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biomedizinische Technik. Biomedical Engineering
R Tobisch, W Irnich
Nō to shinkei = Brain and nerve
M Okawa, Makoto Uchiyama
The Journal of Orthopaedic and Sports Physical Therapy
Charles Philip GabelMarkus Melloh
Journal of the Royal Society of Medicine
Bernard Ribeiro
© 2022 Meta ULC. All rights reserved