Precision medicine in pediatric oncology

Molecular and Cellular Pediatrics
Stefan E G BurdachKlaus-Michael Debatin

Abstract

Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and developed treatment of childhood cancer. Nevertheless, outcome in certain types of malignancies is still unfavorable. Intensification of conventional chemotherapy and radiotherapy improved outcome only marginally at the cost of acute and long-term side effects. Hence, it is necessary to develop targeted therapy strategies.Here, we review the developments and perspectives in precision medicine in pediatric oncology with a special focus on targeted drug therapies like kinase inhibitors and inducers of apoptosis, the impact of cancer genome sequencing and immunotherapy.

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Citations

Jun 16, 2019·Cancers·Silvia TriaricoAntonio Ruggiero
Dec 14, 2019·Cancer Metastasis Reviews·Patricia KattnerKlaus-Michael Debatin
Mar 16, 2019·Science·E Alejandro Sweet-Cordero, Jaclyn A Biegel
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Methods Mentioned

BETA
biopsies
transgenic
transfection

Clinical Trials Mentioned

NCT02101853

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