Nov 6, 2015

Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development

Clinical Pharmacology and Therapeutics
P ViciniM Søgaard

Abstract

High throughput molecular and functional profiling of patients is a key driver of precision medicine. DNA and RNA characterization has been enabled at unprecedented cost and scale through rapid, disruptive progress in sequencing technology, but challenges persist in data management and interpretation. We analyze the state-of-the-art of large-scale unbiased sequencing in drug discovery and development, including technology, application, ethical, regulatory, policy and commercial considerations, and discuss issues of LUS implementation in clinical and regulatory practice.

  • References60
  • Citations6

References

Mentioned in this Paper

United States Food and Drug Administration
Genetic Screening Method
LIUS 3
Sequencing
Pharmacogenomics
Individualized Medicine
Unbiased Estimation
Health Care Systems
Pharmaceutical Preparations
Disease Management

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