Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus

Cell Reports
Aloysius Y T LowAlbert I Chen

Abstract

The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable population of neurons in the mouse interposed anterior nucleus (IntA). We show that these neurons represent a subset of glutamatergic neurons in the IntA and constitute a specific element of an internal feedback circuit within the cerebellar cortex and cerebello-thalamo-cortical pathway associated with limb control. Ablation and optogenetic stimulation of these neurons disrupt efficacy of skilled reach and locomotor movement and reveal that they control positioning and timing of the forelimb and hindlimb. Together, our findings uncover the function of a distinct neuronal subpopulation in the deep cerebellum and delineate the anatomical substrates and kinematic parameters through which it modulates precision of discrete and rhythmic limb movements.

Citations

Jul 14, 2018·The Journal of Comparative Neurology·Gideon A SarpongIzumi Sugihara
May 6, 2020·The FEBS Journal·Gen OhtsukiAkitoshi Ozaki
Jul 10, 2019·Annual Review of Neuroscience·Ludwig Ruder, Silvia Arber
Dec 29, 2020·The Journal of Physiology·Meike E van der HeijdenRoy V Sillitoe
Jul 30, 2021·ELife·Jian-Zhong GuoAdam W Hantman
May 14, 2020·Cell Reports·Anupama SathyamurthyAriel J Levine
Jul 12, 2020·Neuroscience·Ayesha R ThanawallaEiman Azim
Sep 21, 2021·ELife·Elena N JuddAbigail L Person
Jun 9, 2019·Neuron·Matthew I Becker, Abigail L Person

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